数字农科院2.0

The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways

文献类型： 外文期刊

作者： Jingyi Xu;Mingji Xie;Xing Liang;Peida Luo;Xinyao Yang;Jing Zhao;Jinlin Bian;Bo Sun;Qian Tang;Xiao Du;Yao Zou;Weidong Dai;Chunlei He

作者机构：

关键词： anti-inflammation;antioxidant;apoptosis;photodamage;theabrownin;Tibetan tea

期刊名称： Foods

ISSN： 2304-8158

年卷期： 2025 年 14 卷 4 期

页码：

收录情况： SCIE（2025版）

摘要： Ya’an Tibetan tea, renowned as a mysterious tea, has been used as a traditional remedy for disease prevention among ethnic minorities in the Qinghai-Tibet Plateau region, which experiences the highest levels of UVB radiation in the world, for over 1000 years. Theabrownin (TB) from Ya’an Tibetan tea exhibits various health benefits. In this study, the preventive effects of TB on UVB-induced skin damage were investigated. The results showed that TB pretreatment significantly alleviated visible skin damage, epidermal hyperplasia, and collagen destruction in BALB/c mice. The mechanism of action involved increasing the mRNA and protein levels of Nrf2 and enhancing SOD enzyme activity, thereby reducing MDA content and improving the body’s antioxidant capacity. TB also inhibited the protein synthesis of inflammatory factors such as TNF-α, IL-1β, and IL-6, as well as the expression of NF-κB mRNA and protein, thereby reducing skin inflammation. Furthermore, it suppressed the overexpression of p38 MAPK, ERK, and AP-1 mRNA and protein, along with the downstream MMP-1 protein, to prevent collagen destruction in the skin. Additionally, TB pretreatment prevented cell apoptosis by reducing Caspase-3 overexpression. These results suggest that TB can prevent UVB-induced photodamage and exert its preventive effects in a dose-dependent manner by downregulating the MAPK/NF-κB signaling pathway while promoting the Nrf2 signaling pathway in the skin. Consequently, TB holds promising potential for future applications in skin photodamage prevention and skin health promotion.

分类号：

  • 相关文献

[1]Evaluation of Taraxacum mongolicum flavonoids in diets for Channa argus based on growth performance, immune responses, apoptosis and antioxidant defense system under lipopolysaccharide stress. Jia Hua Du,Meng Yue Xu,Yi Wang,Zhao Lei,Zhe Yu,Mu Yang Li. 2022

[2]Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS). Wang, Shaolong,Li, Chong,Zhang, Chaosheng,Liu, Guohua,Zheng, Aijuan,Qiu, Kai,Chang, Wenhuan,Chen, Zhimin. 2023

[3]Effects of Crude Extract of Glycyrrhiza Radix and Atractylodes macrocephala on Immune and Antioxidant Capacity of SPF White Leghorn Chickens in an Oxidative Stress Model. Chaosheng Zhang,Shaolong Wang,Yunsheng Han,Aijuan Zheng,Guohua Liu,Kun Meng,Peilong Yang,Zhimin Chen. 2024

[4]Nutritional composition and antioxidant activity of twenty mung bean cultivars in China. Zhenxing Shi,Yang Yao,Yingying Zhu,GuixingRen. 2016

[5]Multi-targeted antifungal mechanism of punicalagin against Botrytis cinerea and its role in preserving strawberry quality. Muhammad Nawaz,Junkun Pan,Hui Liu,Keying Feng,Jiechao Liu,Wenbo Yang,Zhenzhen Lv,Qiang Zhang,Zhonggao Jiao. 2026

[6]The altitudinal effects on photosynthesis of Rosa platyacantha from the Tianshan Mountains in Northwestern China. Yang, S. H.,Wei, J. J.,Ge, H..

[7]Green extraction, chemical composition, and in vitro antioxidant activity of theabrownins from Kangzhuan dark tea. Liu Y.,Liu H.-Y.,Yang X.,Zhu F.,Wu D.-T.,Li H.-B.,Gan R.-Y.. 2022

[8]Chemical constituents and biological properties of Pu-erh tea. Sunan Wang,Yi Qiu,Ren You Gan,Fan Zhu. 2022

[9]Effects of Key Components on the Antioxidant Activity of Black Tea. Weiwei Wang,Ting Le,Wei Wang,Luting Yu,Lijuan Yang,Heyuan Jiang. 2023

[10]Polysaccharide Conjugates' contribution to mellow and thick taste of Pu-erh ripe tea, besides Theabrownin. Sihan Deng,Tianfang Zhang,Suhang Fan,Huahua Na,Haiyu Dong,Baijuan Wang,Ying Gao,Yong Quan Xu,Xiaohui Liu. 2024

[11]Antioxidative, anti-inflammation and lung-protective effects of mycelia selenium polysaccharides from Oudemansiella radicata. Gao, Zheng,Song, Xinling,Zhang, Jianjun,Wang, Xiuxiu,Jing, Huijuan,Ren, Zhenzhen,Li, Shangshang,Zhang, Chen,Jia, Le,Li, Juan.

[12]Selenium Inhibits LPS-Induced Pro-inflammatory Gene Expression by Modulating MAPK and NF-kappa B Signaling Pathways in Mouse Mammary Epithelial Cells in Primary Culture. Zhang, Wen,Wang, Tiancheng,Jiang, Haichao,Guo, Mengyao,Zhou, Ershun,Sun, Yong,Yang, Zhengtao,Cao, Yongguo,Zhang, Naisheng,Zhang, Runxiang,Xu, Shiwen. 2014

[13]Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-kappa B activation. Zhao, Zhanzhong,Tang, Xiangfang,Zhang, Minhong,Hou, Shaohua,Yuan, Weifeng,Zhang, Hongfu,Shi, Lijun,Jia, Hong,Liang, Lin,Zhao, Zhanzhong,Zhao, Xinghui,Fu, Ling,Chen, Wei,Zhang, Weijian,Lai, Zhi,Gao, Junfeng,Zhang, Keyu. 2014

[14]Anti-Inflammatory Activity of Saponins from Quinoa ( Chenopodium quinoa Willd.) Seeds in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages Cells. Yao, Yang,Yang, Xiushi,Shi, Zhenxing,Ren, Guixing,Yang, Xiushi. 2014

[15]Anti-inflammatory effects of 4 '-demethylnobiletin, a major metabolite of nobiletin. Wu, Xian,Song, Mingyue,Rakariyatham, Kanyasiri,Zheng, Jinkai,Guo, Shanshan,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan,Tang, Zhonghai,Zhou, Shuangde,Xiao, Hang.

[16]Evaluation of Antibacterial and Anti-inflammatory Activities of Less Polar Ginsenosides Produced from Polar Ginsenosides by Heat-transformation. Wang, Lijun,Yang, Xiushi,Yu, Xiaona,Yao, Yang,Ren, Guixing,Wang, Lijun,Yang, Xiushi,Yu, Xiaona.

[17]Synthesis of aspirin eugenol ester and its biological activity. Li, Jian-yong,Yu, Yuan-guang,Wang, Qi-wen,Zhang, Ji-yu,Yang, Ya-jun,Li, Bing,Zhou, Xu-zheng,Niu, Jian-rong,Wei, Xiao-juan,Liu, Xi-wang,Liu, Zhi-qi.

[18]Structural and anti-inflammatory characterization of a novel neutral polysaccharide from North American ginseng (Panax quinquefolius). Wang, Lijun,Yu, Xiaona,Yang, Xiushi,Yao, Yang,Ren, Guixing,Wang, Lijun,Li, Yi,Lui, Edmund Man King.

[19]Antioxidative, Anti-Inflammation And Lung-Protective Effects O.f Mycelia Selenium Polysaccharides F rom Oudemansiella Radicata. Gao, Z, Li, J, Song, XL, Zhang, JJ, Wang, XX, Jing, HJ, Ren, ZZ, Li, SS, Zhang, C, Jia, L. 2017

[20]Identification of anti-inflammatory components in Panax ginseng of Sijunzi Decoction based on spectrum-effect relationship. Kan, Hong,Zhang, Dongxue,Chen, Weijia,Wang, Shihan,He, Zhongmei,Pang, Shifeng,Qu, Shuai,Wang, Yingping. 2023

作者其他论文 更多>>