数字农科院2.0

Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein expression to alleviate its antiviral activity

文献类型： 外文期刊

作者： Yin, Mengge;Qian, Ping;Wang, Haoyuan;Zhao, Qiongqiong;Zhang, Huiyan;Zheng, Zixuan;Zhang, Min;Lu, Zengjun;Li, Xiangmin

作者机构：

关键词： swine zinc-finger protein 36 (sZFP36);foot-and-mouth disease virus (FMDV);3C protease (3C(pro));VP3;VP4

期刊名称： JOURNAL OF VIROLOGY

ISSN： 0022-538X

年卷期： 2024 年

页码：

收录情况： SCIE（2024版）

摘要： Zinc finger protein 36 (ZFP36) is a key regulator of inflammatory and cytokine production. However, the interplay between swine zinc-finger protein 36 (sZFP36) and foot-and-mouth disease virus (FMDV) has not yet been reported. Here, we demonstrate that overexpression of sZFP36 restricted FMDV replication, while the knockdown of sZFP36 facilitated FMDV replication. To subvert the antagonism of sZFP36, FMDV decreased sZFP36 protein expression through its non-structural protein 3C protease (3C(pro)). Our results also suggested that 3C(pro)-mediated sZFP36 degradation was dependent on its protease activity. Further investigation revealed that both N-terminal and C-terminal-sZFP36 could be degraded by FMDV and FMDV 3C(pro). In addition, both N-terminal and C-terminal-sZFP36 decreased FMDV replication. Moreover, sZFP36 promotes the degradation of FMDV structural proteins VP3 and VP4 via the CCCH-type zinc finger and NES domains of sZFP36. Together, our results confirm that sZFP36 is a host restriction factor that negatively regulates FMDV replication.

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