数字农科院2.0

Comprehensive metabolic profiling of dioxin-like compounds exposure in laying hens: Implications for toxicity assessment

文献类型： 外文期刊

作者： Xiaoxu Hu;Tong Xu;Yangsheng Chen;Qian Zhang;Lijuan Tang;Liping Zheng;Chu Wang;Pu Wang;Shujun Dong;Ruiguo Wang;Su Zhang;Qinghua Zhang;Heidi Qunhui Xie;Li Xu;Bin Zhao

作者机构：

关键词： Dioxin-like polychlorinated biphenyls;Laying hens;Metabolomic;Polychlorinated dibenzo-p-dioxins and furans

期刊名称： Journal of Environmental Sciences (China)

ISSN： 1001-0742

年卷期： 2024 年 148 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2024版）

摘要： The evaluation of toxicity related to polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) is crucial for a comprehensive risk assessment in real-world exposure scenarios. This study employed a controlled feeding experiment to investigate the metabolic effects of dioxin-like compounds (DLCs) on laying hens via feed exposure. Diets enriched with two concentrations (1.17 and 5.13 pg toxic equivalents (TEQ)/g dry weight (dw)) were administered over 14 days, followed by 28 days of clean feed. Metabolomics analyses of blood samples revealed significant metabolic variations between PCDD/Fs and DL-PCBs exposed groups and controls, reflecting the induced metabolic disruption. Distinct changes were observed in sphingosine, palmitoleic acid, linoleate, linolenic acid, taurocholic acid, indole acrylic acid, and dibutyl phthalate levels, implying possible connections between PCDD/Fs and DL-PCBs toxic effects and energy-neuronal imbalances, along with lipid accumulation and anomalous amino acid metabolism, impacting taurine metabolism. Moreover, we identified three differential endogenous metabolites—L-tryptophan, indole-3-acetaldehyde, and indole acrylic acid—as potential ligands for the aryl hydrocarbon receptor (AhR), suggesting their role in mediating PCDD/Fs and DL-PCBs toxicity. This comprehensive investigation provides novel insights into the metabolic alterations induced by PCDD/Fs and DL-PCBs in laying hens, thereby enhancing our ability to assess risks associated with their exposure in human populations.

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