数字农科院2.0

Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood

文献类型： 外文期刊

作者： Mingxing Yang;Guowei Xu;Jingyan Zhang;Zhiting Guo;Chao Liang;Yajun Li;Lei Wang;Yuxia Zhou;Yi Ru;Jianxi Li;Xuezhi Wang;Yan Sun

作者机构：

关键词： antiviral effects;extracellular vesicles;feline;IFN-o;miRNA

期刊名称： Journal of Interferon and Cytokine Research

ISSN： 1079-9907

年卷期： 2024 年 44 卷 3 期

页码：

收录情况： SCIE（2024版）

摘要： Feline interferon omega (IFN-o) has been proven to have high antiviral activity; however, its in-depth antiviral effects remain unknown. Extracellular vesicles (EVs) have been demonstrated to participate in the regulation of the immune response pathway for the body through various active substances, especially through the microRNA (miRNA) carried by them. In this study, we isolated EVs from feline peripheral blood by differential centrifugation, and further found that the content of IFN-o in EVs increased continuously within 24 h after IFN-o treatment, and a large number of miRNAs were significantly downregulated in EVs within 12 h after IFN-o treatment. These significantly differentially expressed miRNAs were important for regulating changes in antiviral cytokines. This study reveals for the first time the correlation between EVs-mediated miRNA in feline peripheral blood and IFN-o on antiviral immune response, which may provide strong data support for the development of novel antiviral nanomedicine and the research of the antiviral effects of IFN-o.

分类号：

  • 相关文献

[1]Key miRNAs of chicken seminal plasma extracellular vesicles related with sperm motility regulation. Xintong Han,Yunlei Li,Yunhe Zong,Yi Zhao,Lijun Jiang,Aixin Ni,Hanhan Yang,Jingwei Yuan,Hui Ma,Lin Ma,Jilan Chen,Tenghe Ma,Yanyan Sun. 2024

[2]Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery. Abdul Qadeer,Abdul Wajid,Hafiz Abdul Rafey,Saqib Nawaz,Sawar Khan,Sajid Ur Rahman,Khalid J. Alzahrani,Muhammad Zahoor Khan,Mohammad Nafi Solaiman Alsabi,Hanif Ullah,Sher Zaman Safi,Zanxian Xia,Muhammad Zahoor. 2024

[3]Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals. Wang, Yanjin,Moon, Assad,Huang, Jingshan,Sun, Yuan,Qiu, Hua-Ji. 2022

[4]The function of feline stimulator of interferon gene (STING) is evolutionarily conserved. Zhang, Xiaozhan,Wu, Hongxia,Liu, Chunguo,Sun, Xue,Zu, Shaopo,Tian, Jin,Qu, Liandong,Li, Shoujun,Sun, Xue,Zu, Shaopo,Li, Shoujun.

[5]Investigating Influenza Virus Polymerase Activity in Feline Cells Based on the Influenza Virus Minigenome Replication System Driven by the Feline RNA Polymerase I Promoter. Lu, Gang,Zheng, Feiyan,Ou, Jiajun,Yin, Xin,Li, Shoujun. 2022

[6]Role of feline ANP32 proteins in regulating polymerase activity of influenza A virus. Lu G.,Zheng F.,Xiao Y.,Shao R.,Ou J.,Yin X.,Li S.,Zhang G.. 2024

[7]Rapid detection of feline parvovirus using RAA-CRISPR/Cas12a-based lateral flow strip and fluorescence. Han Chen,Hailing Zhang,Jie Guo,Xiangshu Meng,Mengfan Yao,Longbin He,Xiaoxuan Nie,Han Xu,Chao Liu,Jian Sun,Fei Wang,Yuelong Sun,Zhong Jiang,Yanliang He,Jianlou Zhang,Jianke Wang. 2025

[8]Insights into the structural features of a feline CD8αα homodimer. Rui Ying Liang,Yu Die Cao,Yong Yu Gao,Hai Yang Li,Chen Jun Sang,Yu He Xiu,Dan Li,Da Zhong Liu,Feng Shan Gao,Zi Bin Li. 2025

[9]Roles Of Micrornas In T C.ell Immunity: Implications For S trategy Development Against Infectious Diseases. Giri, BR, Mahato, RI, Cheng, GF. 2019

[10]Extracellular vesicles from Fasciola gigantica induce cellular response to stress of host cells. Guo A.,Wang L.,Meng X.,Zhang S.,Sheng Z.,Luo X.,Huang W.,Wang S.,Cai X.. 2021

[11]Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway. Yuhua Gao,Ningning Mi,Ying Zhang,Xiangchen Li,Weijun Guan,Chunyu Bai. 2022

[12]Comparative Analysis Of Different Extracellular Vesicles Secreted By Echinococcus Granulosus Protoscoleces. Wu, JE, Cai, MT, Yang, J, Li, YT, Ding, JT, Kandil, OM, Kutyrev, I, Ayaz, M, Zheng, YD. 2021

[13]miR-212/132-Enriched Extracellular Vesicles Promote Differentiation of Induced Pluripotent Stem Cells Into Pancreatic Beta Cells. Chunyu Bai,Qiwei Ren,Haifeng Liu,Xiangchen Li,Weijun Guan,Yuhua Gao. 2021

[14]Extracellular vesicles derived from umbilical cord mesenchymal stromal cells alleviate pulmonary fibrosis by means of transforming growth factor-β signaling inhibition. Shi Liyan,Ren Jing,Li Jiping,Wang Dongxu,Wang Yusu,Qin Tao,Li Xiuying,Zhang Guokun,Li Chunyi,Wang Yimin. 2021

[15]Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells. Joshua Seun Olajide,Ling Xiong,Shunli Yang,Zigang Qu,Xiao Xu,Bin Yang,Jing Wang,Baohong Liu,Xueting Ma,Jianping Cai. 2022

[16]Comparative Proteomic Analysis of Milk-Derived Extracellular Vesicles from Dairy Cows with Clinical and Subclinical Mastitis. Mengling Wang,Meng Cai,Xiaoyan Zhu,Xuemei Nan,Benhai Xiong,Liang Yang. 2023

[17]Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells. Zhengmao Xu,Yanan Wang,Meng Sun,Yongzhi Zhou,Jie Cao,Houshuang Zhang,Xuenan Xuan,Jinlin Zhou. 2023

[18]Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host. Joshua Seun Olajide,Zigang Qu,Shunli Yang,Bin Yang,Xiao Xu,Jing Wang,Jianping Cai. 2023

[19]Distribution and Ultrastructural Features of Telocytes in the Pars Distalis of the Rat Pituitary Gland. Chunhua, Liang,Xuebing, Bai,Yonghong, Shi,Min, Yang,Haixiang, Huang,Jianming, Yue,Zhenwei, Zhang,Qiusheng, Chen. 2023

[20]Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. Yuhua Gao,Ningning Mi,Wenxiang Wu,Yuxuan Zhao,Fangzhou Fan,Wangwei Liao,Yongliang Ming,Weijun Guan,Chunyu Bai. 2024

作者其他论文 更多>>