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Allicin attenuates the oxidative damage induced by Aflatoxin B1 in dairy cow hepatocytes via the Nrf2 signalling pathway

文献类型： 外文期刊

作者： Xin Jin;Chenlong Wang;Chuangjiang Chen;Sirao Hai;Sajid Ur Rahman;Chang Zhao;Wanyue Huang;Shibin Feng;Xichun Wang

作者机构：

关键词： Aflatoxin B1;Allicin;Bovine liver cells;Nrf2 signaling pathway;Oxidative stress

期刊名称： Ecotoxicology and Environmental Safety

ISSN： 0147-6513

年卷期： 2024 年 280 卷

页码：

收录情况： SCIE（2024版）

摘要： Aflatoxin B1 (AFB1) is known to inhibit growth, and inflict hepatic damage by interfering with protein synthesis. Allicin, has been acknowledged as an efficacious antioxidant capable of shielding the liver from oxidative harm. This study aimed to examine the damage caused by AFB1 on bovine hepatic cells and the protective role of allicin against AFB1-induced cytotoxicity. In this study, cells were pretreated with allicin before the addition of AFB1 for co-cultivation. Our findings indicate that AFB1 compromises cellular integrity, suppresses the expression of nuclear factor erythroid 2–related factor 2 (Nrf2). In addition, allicin attenuates oxidative damage to bovine hepatic cells caused by AFB1 by promoting the expression of the Nrf2 pathway and reducing cell apoptosis. In conclusion, the results of this study will help advance clinical research and applications, providing new options and directions for the prevention and treatment of liver diseases.

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