数字农科院2.0

Whole-genomic comparison reveals complex population dynamics and parasitic adaptation of Echinococcus granulosus sensu stricto

文献类型： 外文期刊

作者： Yao Dong Wu;Zirui Ren;Li Li;Wen Hui Li;Nian Zhang Zhang;Yan Tao Wu;Guo Dong Dai;Wei Gang Chen;Wen Jie Mu;Shuai Wang;Jiandong Li;Qin Yu;Xue Peng Cai;Xin Jin;Bao Quan Fu;Daxi Wang;Wan Zhong Jia;Hong Bin Yan

作者机构：

关键词： balancing selection;Echinococcus granulosus sensu stricto;introgression;mito-nuclear discordance;population genomics

期刊名称： mBio

ISSN：

年卷期： 2025 年 16 卷 5 期

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收录情况： SCIE（2025版）

摘要： Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu stricto (s.s.), poses a substantial risk to both humans and domestic animals globally. Here, we compared the whole genomes of 111 E. granulosus s.s. samples from China. Genomic variation data revealed frequent cross-fertilization in the hermaphroditic E. granulosus. The G1 and G3 genotypes represent distinct mitochondrial lineages, while showing no differentiation in the nuclear genome, suggesting mito-nuclear discordance caused by historical geographic separation and subsequent fusion. Population structure, demographic history, and gene flow among populations reflected the transmission route of E. granulosus s.s. from the Middle East to Qinghai-Xizang Plateau through the migration of nomadic people, followed by introgression during secondary contact. Genomic variations highlighted selection signatures within the genome prone to balancing selection, particularly impacting genes encoding membrane-related proteins, representing a potential evolutionary strategy for adaptation to parasitic life. Balancing selection pressure on the gene-coding sodium/bile acid cotransporter led to its high level of genetic stability, which may play a crucial role in the survival and development of E. granulosus during the parasitic stage, making it a potential drug target for the treatment of CE. Meanwhile, other genomic regions under strong balancing selection may provide potential targets for protective immunity. These findings offer valuable insights into the complex dynamics and adaptive evolution of E. granulosus s.s. in China.

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