数字农科院2.0

Plant exosome-like nanovesicles derived from sesame leaves as carriers for luteolin delivery: Molecular docking, stability and bioactivity

文献类型： 外文期刊

作者： Jiang, Dan;Li, Ziliang;Liu, Hongyan;Liu, Huihui;Xia, Xiaoyang;Xiang, Xia

作者机构：

关键词： Luteolin;Sesame leaves;Exosomes;Delivery;Stability;Anti-inflammatory activity

期刊名称： FOOD CHEMISTRY

ISSN： 0308-8146

年卷期： 2024 年 438 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： The growing recognition of luteolin (Lu) as a vital functional component is attributed to its notable bioactive properties. However, the effective use of Lu is hindered by its inherent limitations related to water solubility, stability, and bioavailability. Here, we aim to develop sesame leaves-derived exosome-like nanovesicles (Exo) for Lu delivery (Exo@Lu) as vehicles. The encapsulation mechanism, solubility, stability, and bioactivity of Exo@Lu were thoroughly evaluated. Exo enriched abundant lipids, proteins, and phenolic compounds with an encap-sulation efficiency of -91.9 % and a loading capacity of -20.5 % for Lu. The primary binding forces responsible for the encapsulation were hydrogen bonds and van der Waals forces. After encapsulation, the water solubility and stability of Lu were significantly improved under various conditions, including thermal, light, storage, ionic strength, and pH. Exo@Lu maintained structural integrity during simulated digestion, enhancing bioaccessibility and efficacy in mitigating oxidative stress and inflammatory response compared to Exo and free Lu.

分类号：

  • 相关文献

[1]Carotenoids encapsulated in natural flaxseed oil body: Different colloidal interfaces induce their behavior and stability disparity. Shan Zhang,Zhida Sun,David Julian McClements,Bijun Xie,Ruofan Zheng,Qianchun Deng,Yashu Chen. 2024

[2]Flavonoid-rich sesame leaf extract-mediated synthesis of nanozymes: Extraction optimization, chemical composition identification and bioactivity evaluation. Ruiying Zhang,Yufei Liu,Yiqiao Gao,Dengfeng Peng,Qian Luan,Ziliang Li,Xiaoyang Xia,Xia Xiang. 2024

[3]Enhanced Anti-Inflammatory Activities by the Combination of Luteolin and Tangeretin. Funaro, Antonietta,Wu, Xian,Song, Mingyue,Zheng, Jinkai,Guo, Shanshan,Rakariyatham, Kanyasiri,Xiao, Hang,Funaro, Antonietta,Rodriguez-Estrada, Maria Teresa,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan. 2016

[4]Antiviral Activity of Luteolin against Pseudorabies Virus In Vitro and In Vivo. Xiaoyu Men,Su Li,Xiaojing Cai,Lian Fu,Yi Shao,Yan Zhu. 2023

[5]Highly pathogenic porcine reproductive and respiratory syndrome virus-induced inflammatory response in porcine pulmonary microvascular endothelial cells and effects of herbal ingredients on main inflammatory molecules. Wu Y.,Song X.,Li P.,Wang Z.,Zhao Z.,Zhang T.. 2023

[6]Optimal harvest period and quality control markers of cultivated Flos Chrysanthemi Indici using untargeted/targeted metabolomics, chemometric analysis and in vivo study. Peng Yang,Dong Tian,Xiao Yu Han,Qing Jun Zou,Liang Ju Ma,Min Wei,Meng Yu,Zhong Mei Zou. 2024

[7]Exploring synergistic inhibitory mechanisms of flavonoid mixtures on α-glucosidase by experimental analysis and molecular dynamics simulation. Pan, Junkun,Nawaz, Muhammad,Liu, Jiechao,Liu, Hui,Lv, Zhenzhen,Yang, Wenbo,Jiao, Zhonggao,Zhang, Qiang. 2024

[8]A Pectin-Based Active Coating for Preservation of Fresh-Cut Apples: Incorporated with Luteolin and ε-Polylysine for Enhanced Performance. Li, Chengheng,Pan, Junkun,Nawaz, Muhammad,Liu, Hui,Lv, Zhenzhen,Yang, Wenbo,Zhang, Qiang,Liu, Jiechao,Jiao, Zhonggao. 2025

[9]Evaluating the risk of phosphorus loss with a distributed watershed model featuring zero-order mobilization and first-order delivery. Li, Sisi,Zhang, Liang,Zhuang, Yanhua,Feng, Qi,Du, Yun,Liu, Hongbin,Zhai, Limei,Lei, Qiuliang,Li, Wenchao,Liu, Hongbin,Zhai, Limei,Lei, Qiuliang,Li, Wenchao,Loaiciga, Hugo A.,Hu, Wanli.

[10]Immunization of mice by Hollow Mesoporous Silica Nanoparticles as carriers of Porcine Circovirus Type 2 ORF2 Protein. Sun, Shi-Qi. 2012

[11]Chitosan-based Pickering emulsion: A comprehensive review on their stabilizers, bioavailability, applications and regulations. Meng W.,Sun H.,Mu T.,Garcia-Vaquero M.. 2023

[12]Pickering Emulsion Stabilized by Tea Seed Cake Protein Nanoparticles as Lutein Carrier. Li Liang,Junlong Zhu,Zhiyi Zhang,Yu Liu,Chaoting Wen,Xiaofang Liu,Jixian Zhang,Youdong Li,Ruijie Liu,Jiaoyan Ren,Qianchun Deng,Guoyan Liu,Xin Xu. 2022

[13]The roles of flaxseed gum and its oligosaccharides as stabilizers in zein nanoparticles for apigenin delivery: Stability, antioxidant activity, bioavailability, molecular simulations. Yufei Liu,Ziliang Li,Shuaijun Lu,Shang Gao,Mengting Xu,Ze Yuan,Yue Li,Yiqiao Gao,Jingfang Shangguan,Xia Xiang. 2025

[14]Bioactive sulforaphane from cruciferous vegetables: advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applications. Zhang, Yanli,Zhang, Wenyuan,Zhao, Yaqi,Peng, Renjie,Zhang, Zhanquan,Xu, Zhenzhen,Simal-Gandara, Jesus,Yang, Haixia,Deng, Jianjun. 2024

[15]Detection of lunasin in quinoa (Chenopodium quinoa Willd.) and the in vitro evaluation of its antioxidant and anti-inflammatory activities. Ren, Guixing,Ren, Guixing,Zhu, Yingying,Shi, Zhenxing,Zhu, Yingying,Shi, Zhenxing,Li, Jianhui.

[16]EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG SAN. Wang, Lei,Wang, Xurong,Zhang, Jingyan,Yang, Zhiqiang,Liu, Youbin,Cui, Dongan,Qin, Zhe,Meng, Jiaren,Kong, Xiaojun,Wang, Xuezhi,Li, Jianxi. 2015

[17]Analgesic and anti-inflammatory effects of hydroalcoholic extract isolated from Semen vaccariae. Wang, Lei,Cui, Dongan,Wang, Xurong,Zhang, Jingyan,Yang, Zhiqiang,Qin, Zhe,Kong, Xiaojun,Wang, Xuezhi,Li, Jianxi. 2015

[18]A Novel Polymeric Nanohybrid Antimicrobial Engineered by Antimicrobial Peptide MccJ25 and Chitosan Nanoparticles Exerts Strong Antibacterial and Anti-Inflammatory Activities. Yu Haitao,Chen Yifan,Sun Mingchao,Han Shuaijuan. 2022

[19]Chemical constituents, antibacterial, acaricidal and anti-inflammatory activities of the essential oils from four Rhododendron species. Jian He,Xiaofei Shang,Lixia Dai,Xiaorong Yang,Bing Li,Yanming Wei,Jiyu Zhang,Hu Pan. 2022

[20]C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo. Li, Ting,Yang, Na,Teng, Da,Mao, Ruoyu,Hao, Ya,Wang, Xiumin,Wang, Jianhua. 2022

作者其他论文 更多>>