Cross-regional dynamics of antibiotic resistance (AR): Genomic evidence of transmission for Escherichia coli carrying last-resort AR gene between food animals and humans in China
文献类型: 外文期刊
作者: Jie Hou;Ye Li;Qinglin Chen;Mengqi Liu;Yi An;Fengxia Yang;Yanpo Yao
作者机构:
关键词: Escherichia coli;Food animals;Genome sequences;Human beings;Last-resort antibiotic resistance genes;Transmission
期刊名称: Eco-Environment and Health
ISSN:
年卷期: 2025 年 5 卷 1 期
页码:
收录情况: CSCD(2025-2026年度) ; ; ESCI(2025版)
摘要: The rapidly increasing dissemination of antibiotic-resistant bacteria (ARB) among food animals and humans is a burgeoning public health crisis. Yet, our understanding of ARB transmission is largely constrained to regional studies, with a dearth of insights into cross-regional dynamics. In this study, the whole-genome sequences of >800 E. coli strains harboring last-resort antibiotic resistance genes (LARGs) across 20 regions of China were retrieved from the NCBI RefSeq database. Our analysis uncovered that 1767 human–animal isolate pairs exhibited high homology, with the pairwise average nucleotide identity (ANI) values exceeding 99.5%. By employing phylogenetic analysis, transmission cluster identification, ANI, and single-nucleotide polymorphism (SNP) analysis, 42 human–animal transmission clusters and 306 recent transmission events were identified. Strikingly, more than 90% of these human–animal transmission events (284 out of 306) spanned different regions. Counterfactual analysis indicated that the cross-regional transmission significantly contributes to the prevalence of these ARBs in humans (21.62%), while its role in the food-animal epidemic is less pronounced (3.47%). Our findings underscore the urgency of a more integrated, nationwide approach to address the spread of LARG-harboring bacteria, which is essential to preserving the efficacy of our remaining antibiotic arsenal and safeguarding public health on a global scale.
分类号:
- 相关文献
作者其他论文 更多>>
-
Recent advances and prospects of iron-based biochar for antibiotic removal: Unveiling the dual mechanisms of adsorption and degradation
作者:Junjie Wang;Yifan Liu;Xue Li;Ran Zhao;Xiaoquan Mu;Fengxia Yang;Haixin Guo;Yongzhen Ding
关键词:Adsorption;Advanced oxidation processes;Antibiotic Removal;Iron-based biochar;Reactive oxygen species
-
Effects of biochar combined with Trichoderma brevicompactum 6311 on pepper phytophthora blight and pepper growth
作者:Jien Zhou;Junfeng Liang;Xueyan Zhang;Yanli Luo;Zheng Qu;Tongguo Gao;Yanpo Yao;Feng Wang
关键词:Biocontrol microorganisms;Disease suppression;Growth promotion;Pepper phytophthora blight;Soil health;Trichoderma brevicompactum
-
Mechanistic insights into degradation of yam waxiness for freeze-thaw: The interference of ice crystals on dynamic behavior of starch chains
作者:Ye Li;Zhenjiang Zhou;Weisu Huang;Shengyang Ji;Linchun Mao;Wenhui Yu;Fengzhong Wang;Baiyi Lu
关键词:Freeze-thaw;MD;Molecular dynamics simulation;Starch;Waxiness
-
Efficient allelochemical removal from continuous capsicum cultivation using horseradish peroxidase–loaded biochar
作者:Xueyan Zhang;Shiyu Lv;Tian Yuan;Kerong Fu;Pu Yang;Yanpo Yao;Junfeng Liang;Tongguo Gao;Feng Wang
关键词:Biochar;Degradation;Ferulic acid;Horseradish peroxidase;Immobilization;Self-toxic substances
-
A review of organophosphorus esters in soil: Pollution status, migration, risks, and transformation
作者:Yu Cheng;Xuehao Zheng;Cuihua Hu;Qing Luo;Xingyi Liu;Shoujiang Liu;Peng He;Keke Chang;Fengxia Yang;Yongzhen Ding
关键词:Distribution;Migration;Organophosphorus esters;Soil;Source;Toxicity;Transformation
-
Self-assembed Fe-doped tobacco straw rich in lignin biochar towards efficient activation of peroxymonosulfate for sulfonamide elimination: Characterization, experimental study, and theoretical calculation
作者:Yunjie Wu;Zhenhua Wang;Quanbin Zhang;Huifu Ji;Youqi Zhang;Bo Fu;Fengxia Yang;Yongzhen Ding;Huanhuan Wang
关键词:Degradation pathways;Self-assembly Fe-doping;Sulfonamides
-
Significant effects of earthworm species on antibiotic resistome in livestock manure as revealed by metagenomic analysis
作者:Ming Yang;Liang Peng;Meirui Mu;Fengxia Yang;Zhonghan Li;Bingjun Han;Keqiang Zhang
关键词:Antibiotic resistance genes;Earthworm species;Livestock manure;Microbial communities;Vermicomposting