数字农科院2.0

Kinetic-Controlled Synthesis of Walnut-like Core–Shell Magnetic Mesoporous Silica Microspheres for Enhanced Enzyme Loading and Biocatalytic Performance

文献类型： 外文期刊

作者： Zhonglin He;Yuqi Fan;Rongju Zhou;Baozhu Zhao;Xingxing Ding;Jin Mao;Jie Shi

作者机构：

关键词： biocatalysts;core−shell structure;enzyme immobilization;mesoporous materials;phytosterol esters

期刊名称： Journal of Agricultural and Food Chemistry

ISSN： 1520-5118

年卷期： 2025 年 73 卷 39 期

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Magnetic mesoporous materials, integrating magnetic nanoparticles and mesoporous structures, have great potential in biomedicine, catalysis, and the environment. This study develops a novel core–shell nanocarrier (CS-WMM: magnetic core-flower-like MnO2mesoporous layer-silica shell) for efficient lipase immobilization and enhanced phytosterol esters synthesis. Via a surfactant-free kinetic-controlled interfacial assembly, walnut-like dual-mesoporous microspheres (inner flower-like MnO2, outer mesoporous SiO2: 4.8 nm pore, 158.61 m2/g surface) are constructed, enabling a high enzyme loading (210 mg g–1) and improved substrate diffusion. Compared with Fe3O4@MnO2, CS-WMM achieves 78.33% esterification conversion and retains 55.03% activity after 7 cycles via dual-mesoporous synergy. This work provides a novel material design strategy with high loading capacity and structural stability for hydrophobic substrate-driven biocatalytic systems, which holds potential applications in food lipid processing, biopharmaceuticals, and other fields.

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