数字农科院2.0

Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

文献类型： 外文期刊

作者： Zhanding Cui;Jinlong Liu;Jinlong Wang;Jing Zhang;Yimei Cao;Kun Li;Zhixun Zhao;Hong Yuan;Xingwen Bai;Xueqing Ma;Pinghua Li;Yuanfang Fu;Huifang Bao;Dong Li;Qiang Zhang;Zaixin Liu;Kai Li;Tong Xu;Zengjun Lu

作者机构：

关键词： antiviral agent;formononetin;mizoribine;Porcine Reproductive and Respiratory Syndrome;swine viral infections

期刊名称： Frontiers in Nutrition

ISSN： 2296-861X

年卷期： 2025 年 11 卷

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收录情况： SCIE（2025版）

摘要： This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains in vitro, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.

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