数字农科院2.0

Artemether ameliorates DSS-induced ulcerative colitis by modulating macrophage polarization

文献类型： 外文期刊

作者： Xinxin Ren;Yi Li;Jia Xu;Ye Xu;Kunlun Huang;Baiqiang Zhai;Xiaoyun He

作者机构：

关键词： Artemether;Immunomodulatory;Macrophage;Notch signal pathway;Ulcerative colitis

期刊名称： International Immunopharmacology

ISSN： 1567-5769

年卷期： 2025 年 161 卷

页码：

收录情况： SCIE（2025版）

摘要： Ulcerative colitis (UC) is a type of human intestinal disease with limited therapeutic options and a low cure rate. The difficulty in treating UC is partly attributed to its complex immune regulatory mechanisms. Artemether, a derivatives of artemisinin, has shown significant therapeutic potential in treating immune-related diseases, such as systemic lupus erythematosus and atherosclerosis. This study aimed to explore the potential ameliorative effects and mechanisms of artemether in UC mice. Through in vivo and in vitro experiments, we found that artemether improved colon inflammation and intestinal barrier dysfunction in mice by decreasing the levels of inflammatory factors IL-1β and IL-6, promoting the upregulation of tight junction proteins ZO-1 and Occludin, and inhibiting intestinal leakage. These effects may be mediated by regulating Notch signaling activation and suppressing pro-inflammatory M1 macrophages. This discovery provides new potential therapeutic strategies for colitis.

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