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Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota

文献类型： 外文期刊

作者： Jianlong Lao;Man Chen;Shuping Yan;Han Gong;Zhaohai Wen;Yanhong Yong;Dan Jia;Shuting Lv;Wenli Zou;Junmei Li;Huiming Tan;Hong Yin;Xiangying Kong;Zengyuan Liu;Fucheng Guo;Xianghong Ju;Youquan Li

作者机构：

关键词： Gut microbiota;Inflammatory;Lacticaseibacillus rhamnosus G7;Probiotics

期刊名称： BMC Microbiology

ISSN： 1471-2180

年卷期： 2025 年 25 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, Lacticaseibacillus rhamnosus G7 isolated from herdsmen yogurt was used. The results of the in vitro evaluation revealed that it had good tolerance and safety. In mice with colitis, G7 alleviated weight loss and colon shortening and reduced the DAI score. After G7 treatment, the levels of proinflammatory factors (IL-1β, IL-6 and TNF-α) and histopathological scores decreased, whereas the level of IL-10 increased. In addition, G7 rebalanced the intestinal microbial composition of colitis model mice by increasing the abundance of Faecalibaculum and decreasing the abundance of Bacteroides and Escherichia_Shigella. In summary, G7 has great potential in the prevention of colitis.

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