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弓形虫弱毒疫苗的研究进展

文献类型： 中文期刊

作者： 张海生;马元元;谢世臣;梁勤立;朱兴全;王金磊

作者机构：

关键词： 弓形虫;疫苗;CRISPR-Cas9;基因编辑

期刊名称：中国人兽共患病学报

ISSN： 1002-2694

年卷期： 2021 年 37.0 卷 5.0 期

页码：

收录情况： 北大核心（2020版） ; CSCD（2020-2021年度） ; 科技核心（2020版）

摘要： 弓形虫是一种专性细胞内寄生原虫,可感染包括人在内的几乎所有的温血动物,全球约有1/3的人口感染弓形虫病。宿主感染弓形虫后常呈隐性感染,但对于免疫力低下的人群,如艾滋病患者或者孕妇,可引起严重的临床症状甚至死亡。随着人类生活质量的不断提高,弓形虫给人类健康、畜牧业发展和公共卫生安全带来的隐患与日俱增。目前,尚无针对弓形虫病的特效药,疫苗将是控制弓形虫病最有效的手段。传统的弓形虫疫苗免疫效果较差,自然筛选获得的弱毒苗存在返毒的可能,不适用于免疫缺陷的动物或人群。传统基因编辑技术构建基因敲除株的效率低且过程复杂。随着基因编辑技术CRISPR-Cas9在弓形虫研究中的应用,为研制弓形虫疫苗提供了新的方向,已成功构建了许多弱毒疫苗虫株,这些虫株具有很好的免疫保护作用,是弓形虫疫苗最有希望的候选者。本文综述弓形虫弱毒疫苗的研究进展和发展前景,为弓形虫疫苗的后续研究提供参考。

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