数字农科院2.0

芩连液与白虎汤对脂多糖致家兔肝损伤的疗效比较

文献类型： 中文期刊

作者： 张世栋;王东升;李世宏;李宏胜;荔霞;李锦宇;陈炅然;龚成珍;严作廷

作者机构：

关键词： LPS;肝损伤;血清生化指标;中药;组方

期刊名称：中国畜牧兽医

ISSN： 1671-7236

年卷期： 2011 年 38 卷 07 期

页码： 183-186

收录情况： 北大核心

摘要： 为比较自拟方芩连液和白虎汤对高热病症的治疗效果,通过静脉注射脂多糖(LPS)复制了家兔高热病症,并在两种药物治疗前后分别进行了肝脏组织病理观察与血清生化指标分析。结果显示,15μg/kg LPS能致家兔肝脏组织产生明显病理损伤,血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和尿素(Urea)含量上升,而总胆固醇(TC)含量下降,经白虎汤和芩连液治疗后肝脏组织病理损伤显著减轻,4项血清生化指标向正常水平恢复。结果表明,白虎汤和芩连液对LPS引起的肝损伤都具有显著的治愈效果,且两种组方的疗效各有优势。

分类号： R285.5

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