数字农科院2.0

脂肪相关lncRNAs在动物中的研究进展

文献类型： 中文期刊

作者： 刘怡冰;敖红;邢凯;王楚端

作者机构：

关键词： lncRNAs;脂肪发育;调控机制

期刊名称：中国畜牧兽医

ISSN： 1671-7236

年卷期： 2019 年 7 期

页码： 2021-2029

收录情况： 北大核心（2020版） ; 农林核心（2020版） ; 科技核心（2020版）

摘要： 脂肪是动物体内重要的储能物质,与动物的瘦肉率等重要的经济性状密切相关.脂肪发育是一个复杂而精密的过程,受到多种脂肪生成相关基因、转录调节因子及表观遗传因子的共同调控.长链非编码RNAs(long non-coding RNAs,lncRNAs)是一类长度>200 nt的非编码RNAs,可以在转录、转录后及表观修饰等多个水平上调节靶基因的表达,进而调控生命活动.近年来有关lncRNAs的研究逐渐增多,其作用范围几乎覆盖了生命活动的各个方面,也有一些lncRNAs被证实在脂肪发育的过程中发挥重要的调控作用,如棕色脂肪lncRNA 1(Blnc1)可以通过核糖核蛋白复合物促进棕色和米色脂肪细胞分化,该复合物也能够与早期B细胞因子2(Ebf2)起作用以增强产热基因如解偶联蛋白1(Ucp1)的表达;lnc-BATE1是棕色脂肪组织形成和结合异质核核糖核蛋白U(hnRNPU)以发挥产热作用所需的调控因子;lncRNA SRA能与过氧化物酶体增殖物激活受体γ(PPARγ)结合并增强PPARγ活性及其他多种途径,促进前脂肪细胞向脂肪细胞的分化,进一步调控脂肪的功能.作者对lncRNAs的基本特征、作用机制及其研究方法等,以及国内外对于脂肪发育相关lncRNAs的研究结果进行了综述,以期为进一步探索lncRNAs对脂肪发育的调控机制提供参考.

分类号： S813.1

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