数字农科院2.0

TaHSP90 stabilizes Lr13 to regulate temperature-sensitive resistance to leaf rust in wheat seedlings

文献类型： 外文期刊

作者： Wang, Xinhai;Zhang, Jiaomeng;Gao, Pu;Gebrewahid, Takele Weldu;Li, Gang;Dong, Haijiao;Wang, Shuo;Niu, Shijie;Zhang, Peipei;Li, Zaifeng

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期刊名称： CELL REPORTS

ISSN： 2639-1856

年卷期： 2025 年 44 卷 11 期

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收录情况： SCIE（2025版）

摘要： Escalating wheat leaf rust disease pressure under climate warming threatens global wheat production security, necessitating the development of durable leaf rust resistance as a strategy to counter emerging threats. Through transcriptomic analysis and histochemical staining, this study demonstrated that Lr13 induced higher levels of salicylic acid (SA) signaling and reactive oxygen species (ROS) accumulation at 25 degrees C compared to 18 degrees C. Using affinity purification coupled with mass spectrometry (AP-MS) and protein interaction assays, TaHSP90 was identified as a thermoregulatory Lr13-interacting protein during infection by the leaf rust pathogen Puccinia triticina (Pt). Lr13 bypassed 26S-proteasome-mediated degradation by combining with HSP90-RAR1, thus maintaining SA-related gene expression and ROS burst at the higher temperature. Our findings demonstrate that TaHSP90 positively regulates the temperature-sensitive leaf rust resistance conferred by Lr13 in wheat, offering strategic insights to combat rust diseases.

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