数字农科院2.0

Ecological drivers and functional roles of phage communities in the Yangtze River's freshwater ecosystems

文献类型： 外文期刊

作者： Liang Peng;Fengxia Yang;Jing Zhang;Jiayu Shang;Wei Xu;Shoushan Sheng;Qinfen Li;Yukun Zou;Zhengfu Yue

作者机构：

关键词： Elevation;Functional genes;Phage;Virus-host interactions;Yangtze River

期刊名称： Journal of Hazardous Materials

ISSN： 0304-3894

年卷期： 2025 年 500 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The Yangtze River, China's largest and most significant freshwater system, is facing increasing pollution pressures due to rapid urbanization. While bacterial-mediated antibiotic resistance has been extensively studied, the functional roles and ecological risks of phage communities remain poorly understood. Here, we conducted a comprehensive virome analysis across four habitats (free-living setting, particle-associated setting, sediment, and bank soil) using 204 samples from the Yangtze River. We identified 18,865 viral operational taxonomic units (vOTUs) and observed significant correlations between viral communities and metagenome-assembled genomes (MAGs) across all habitats. Notably, the virus-to-host ratio (VHR) decreased significantly with increased elevation. Functional annotation revealed 1367 viruses contigs carrying genes associated with six functional categories, each showing distinct habitat-specific patterns. Carbohydrate-degrading enzymes (CAZy) were abundant in free-living setting water. Among phage-borne ARGs, vancomycin resistance was predominated, especially in sediment and bulk soil, while mercury resistance were most prevalent in sediments. Chitinase genes constituted the most abundant group among phage-encoded genes for plastic degradation. We identified 84 high-confidence virus-host pairs, predominantly infecting Proteobacteria. Random forest modeling identified elevation as the dominant driver of viral community abundance across habitats. Higher elevations were correlated with increased pH and reduced NH₄⁺-N concentrations, suggesting nutrient limitation may weaken virus-host interactions. This study provides the first systematic assessment of viral diversity and functional potential in the Yangtze River, offering novel insights into phage ecology in freshwater.

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