数字农科院2.0

Advances of functional nucleic acids based on specific recognition:A review

文献类型: 外文期刊

作者: Beibei Liu;Ge Chen;A. M. Abd El-Aty;Rongqi Zhai;Guangyang Liu;Xiaomin Xu;Yanguo Zhang;Lingyun Li;Jie Zhang;Donghui Xu

作者机构:

关键词: Application;Functional nucleic acids;Specific recognition

期刊名称: International Journal of Biological Macromolecules

ISSN: 0141-8130

年卷期: 2025 年 304 卷

页码:

收录情况: SCIE(2025版) ; ; EI(2025版)

摘要: Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis. This review focuses on the structure and specific recognition principles of FNAs, followed by an exploration for biosensing and biomedical applications, offering insights into current challenges and future trends in FNAs as recognition elements.

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