数字农科院2.0

Optimizing the Size of Zr-Based Metal-Organic Frameworks for Enhanced Anticancer Efficacy

文献类型： 外文期刊

作者： Cheng, Zan;Yu, Mei;Wan, Yilong;Xiang, Huandong;Wei, Haoran;Zu, Xu;Li, Xin;Zhang, Ruiting;Li, Fangshu;Wang, Shanshan;She, Yongxin

作者机构：

关键词： metal-organic frameworks;UiO-67;drug delivery;cellular internalization;anticancer

期刊名称： NANOMATERIALS

ISSN：

年卷期： 2025 年 15 卷 11 期

页码：

收录情况： SCIE（2025版）

摘要： Metal-organic frameworks (MOFs) have great potential for drug delivery systems due to their tunnel pore size, structural versatility, and high surface area. Among them, UiO-67 have recently attracted substantial attention as functional nanocarriers for effective delivery of small molecule chemical drugs. However, the influence of the size on cellular uptake of UiO-67 remains ambiguous. Here, we use polyvinyl pyrrolidone (PVP) as the capping agent of UiO-67 to synthesize spherical Zr-based MOFs with various diameters, including 40 nm, 60 nm, and 120 nm. The highest cellular uptake is observed in the case of Zr-based MOFs with a diameter of 40 nm (PU40 MOFs). Moreover, doxorubicin can be loaded into the inner pores of PU40 MOF via pi-pi and electrostatic interactions (DPU40 MOFs), with a loading capacity of 82 wt%, and gradually released under acidic conditions. In vitro, the resulting DPU40 MOFs can be internalized by cancer cells more effectively, thereby enhancing the delivery of doxorubicin into cancer cells. Ultimately, this results in enhanced antitumor efficacy toward 4T1, Hs 578T, and MCF-7 cells. Our findings indicate that approximately 40 nm may be the optimum diameter for the special Zr-based MOFs to be internalized by cells more effectively, providing potent potential nanocarriers for drug delivery.

分类号：

  • 相关文献

[1]Metal-organic framework-mediated antioxidant enzyme delivery in disease treatment. Jiang Yayun,Ge Qianqian,Sun Xihang,Hong Yang,Hou Zhenping,Li Yuying,Ma Xiancheng,Jiang Qian,Shi Pengjun. 2025

[2]Polyphenolic Nanomedicine Regulating Mitochondria REDOX for Innovative Cancer Treatment. Mingchuan Yang,Yufeng He,Qingqing Ni,Mengxue Zhou,Hongping Chen,Guangyun Li,Jizhong Yu,Ximing Wu,Xiangchun Zhang. 2024

[3]The application of virus-like particles as vaccines and biological vehicles. Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi,Yan, Dan,Wei, Yan-Quan,Guo, Hui-Chen,Sun, Shi-Qi.

[4]Foot-And-Mouth Disease Virus-Like Particles As I.ntegrin-Based Drug Delivery System A chieve Targeting Anti-Tumor Efficacy. Yan, D,Teng, ZD,Sun, SQ,Jiang, S,Dong, H,Gao, Y,Wei, YQ,Qin, WW,Liu, XT,Yin, H,Guo, HC. 2017

[5]Self-assembled thiophanate-methyl/star polycation complex prevents plant cell-wall penetration and fungal carbon utilization during cotton infection by Verticillium dahliae. Xiaofeng Su,Shuo Yan,Weisong Zhao,Haiyang Liu,Qinhong Jiang,Ying Wei,Huiming Guo,Meizhen Yin,Jie Shen,Hongmei Cheng. 2023

[6]Self-Assembled Nanonematicide Induces Adverse Effects on Oxidative Stress, Succinate Dehydrogenase Activity, and ATP Generation. Peng, Huan,Jian, Jinzhuo,Long, Haibo,Jiang, Qinhong,Huang, Wenkun,Kong, Lingan,Yin, Meizhen,Shen, Jie,Su, Xiaofeng,Peng, Deliang,Yan, Shuo. 2023

[7]Multi-templates molecularly imprinted polymers for simultaneous recognition of multiple targets: From academy to application. Shenling Wang,Le Zhang,Jing Zeng,Xiaofeng Hu,Xiupin Wang,Li Yu,Du Wang,Ling Cheng,Rajib Ahmed,Valentin Romanovski,Peiwu Li,Zhaowei Zhang. 2023

[8]Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system. Yingrui Li,Ze Chen,Jia Guo,Deshuang Meng,Xin Pang,Zepeng Sun,Li Pu,Shuiyue Yang,Min Yang,Yinghua Peng. 2024

[9]Preparation of salicylic acid nano-protectant with dual synergistic mechanism: High direct fungicidal activity and plant defence toward cotton Verticillium wilt. Jiaming Yin,Jiajia Zhao,Zeng Wang,Fan Xue,Qi Wang,Huiming Guo,Hongmei Cheng,Jie Li,Jie Shen,Meizhen Yin,Xiaofeng Su,Shuo Yan. 2024

[10]Current and emerging applications of saccharide-modified chitosan: a critical review. Hamed Kazemi Shariat Panahi,Mona Dehhaghi,Hamid Amiri,Gilles J. Guillemin,Vijai Kumar Gupta,Ahmad Rajaei,Yadong Yang,Wanxi Peng,Junting Pan,Mortaza Aghbashlo,Meisam Tabatabaei. 2023

[11]Preparation of a Fluxapyroxad Nanoformulation with Strong Plant Uptake for Efficient Control of Verticillium Wilt in Potato. Wang, Dong,Weng, Huiting,Zhao, Yuanzheng,Zhou, Hongyou,Guo, Huiming,程红梅、Shen, Jie,Yin, Meizhen,Yan, Shuo,Su, Xiaofeng. 2025

[12]Recent advances in tea and other plant polyphenol biomaterials for antibacterial and disease treatment. Shanshan Wang,Ziqi Wang,Zuguang Li,Xiangchun Zhang,Hongping Chen. 2025

[13]Edible ginseng-derived exosomes as drug delivery vehicles reduce the dose and improve the anti-cancer effect of CDDP. Shuiyue Yang,Jia Guo,Shan Huang,Zepeng Sun,Min Yang,Yinghua Peng. 2025

[14]Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery. Shuhan Feng,Patrick Laurén,Jacopo Zini,Zahra Gounani,Jinfeng Bi,Jianyong Yi,Timo Laaksonen. 2025

[15]NQO1-responsive Trimethyl lock benzoquinone: A cleavable linker strategy for antibody-drug conjugates. Wang, Zihao,Liu, Kai,Shang, Chao,Yan, Xiangyu,Dong, Yuchao,Li, Dapeng,Li, Yiquan,Zhang, Cuiling,Ren, Wei,Ma, Chengyuan,Wang, Huan,Li, Xiao,Fan, Shiyong,Zhong, Wu. 2025

[16]Metal organic frameworks as sacrificial templates for preparation of hierarchical covalent organic frameworks enabling ultrafast sample treatment in nontargeted food safety analysis. Wei Li,Rong-Zhi Gao,Hong-Xin Jiang,Qiu-Yu Lu,An-Na Tang,De-Ming Kong. 2021

[17]Novel Fe3O4@metal-organic framework@polymer core-shell-shell nanospheres for fast extraction and specific preconcentration of nine organophosphorus pesticides from complex matrices. Mengfei Wan,Fachun Xiang,Zhongdong Liu,Denggao Guan,Yong Shao,Lufei Zheng,Maojun Jin,Yongxin She,Liping Cao,Fen Jin,Rui Chen,Shanshan Wang,Yijun Wu,A. M. Abd El-Aty,Jing Wang. 2021

[18]Synthesis of metal-organic framework @molecularly imprinted polymer adsorbents for solid phase extraction of organophosphorus pesticides from agricultural products. Yang Li,Bingzhi Li,Yan Qi,Ziping Zhang,Shuang Cong,Yongxin She,Xiaolin Cao. 2022

[19]Effective Extraction of Bisphenol Compounds from Milk with Stable Zr(IV)-Based Metal-Organic Framework Particles. Li, Tong,Wang, Ruiguo,Yin, Ruijie,Xu, Hongyan,Han, Xiaoxu,Du, Qiuling,Cheng, Jie,Lin, Zhenyu,Wang, Peilong. 2023

[20]Multifunctional ?-Cyclodextrin-Based Metal-Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity. Chen, Huiping,Shan, Yongpan,Xu, Chunli,Bilal, Muhammad,Zhao, Pengyue,Cao, Chong,Zhang, Hongjun,Huang, Qiliang,Cao, Lidong. 2023

作者其他论文 更多>>