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LC-MS/MS Guided Discovery of Japonamides C and D, Two New Cyclohexadepsipeptides from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus japonicus TE-739D

文献类型： 外文期刊

作者： Haisu Wang; Xianwei Hao; Chen Dong; Xiaolong Yuan; Peng Zhang; Gan Gu

关键词： endophytic fungus; Aspergillus japonicas; cyclohexadepsipeptides; cell proliferation inhibitory activity; japonamides

期刊名称： Frontiers in Microbiology

ISSN：

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Endophytic fungi belonging to Aspergillus genus have received substantial attention due to their attractive secondary metabolic potential. In this study, chemical investigations by using LC-MS/MS based molecular networking on the endophytic fungus Aspergillus japonicus TE-739D yielded two new cyclohexadepsipeptides, namely, japonamides C (1) and D (2), together with three known cyclodipeptides (3−5). Their structures including the absolute configurations of the amino acid residues were elucidated by spectroscopic data analyses and optimized Marfey’s method. The new compounds japonamides C (1) and D (2) were screened for broad-spectrum cell proliferation inhibitory activities against 20 different human cell lines. The results indicated that both two compounds displayed broad-spectrum antiproliferative activities against MKN-45, HCT116, TE-1, 5637, CAL-62, and A-637 cells, with the inhibition rates ranging from 55.0% to 72.3%. Moreover, the antibacterial activities of the compounds 1−5 against two Gram-positive bacteria and two Gram-negative bacteria were also evaluated.

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