数字农科院2.0

Genome mining leads to rare calbistrin derivatives with potent herbicidal activity from the endophytic fungus Aspergillus japonicus TE-739D

文献类型： 外文期刊

作者： Gan Gu; Haisu Wang; Lei Du; Zetian Qiu; Xiaolong Yuan; Peng Zhang

关键词： endophytic fungus; Aspergillus japonicus; secondary metabolite; calbistrin derivatives; herbicidal activity

期刊名称： JOURNAL OF ORGANIC CHEMISTRY

ISSN： 0022-3263

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Genomic mining identified a distinct cal'' biosynthetic gene cluster from the endophytic fungus Aspergillus japonicus TE-739D, thereby leading to the discovery of nine novel calbistrin derivatives, namely japonidienes A−I (1−9), along with three known analogs (10−12). Their structures were elucidated by spectroscopic data analyses and quantum chemical calculations. Notably, compound 1 possessed a unique scaffold, in which the polyene moiety generated a cyclopentanone motif. Based on bioinformatic analyses and homology comparisons with reported calbistrin pathways, a hypothetical biosynthetic route for these isolated calbistrin-type compounds was proposed, which demonstrated an elegant example of modular polyketide assembly and diversified post-modifications. Compound 6 demonstrated potent herbicidal efficacy in suppressing Eleusine indica when compared to the positive control glyphosate. Further mechanistic investigations employing transcriptomic and proteomic analyses revealed that compound 6 disrupted MAPK signaling and influenced ABA-mediated seed dormancy pathways. This study is the first to report the herbicidal activity of the rare calbistrin-type compounds, highlighting their potential as candidates for natural herbicide development.

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