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An adenovirus-vectored recombinant vaccine confers passive immunity protection from swine acute diarrhea syndrome coronavirus challenge in neonatal mice

文献类型： 外文期刊

作者： Zhang, Yu;Duan, Yueyue;Zhu, Xueliang;Shi, Lei;Zhang, Juan;Mao, Wenquan;Li, Luyao;Yuan, Cong;Sun, Maowen;Zheng, Haixue;Wang, Qi

作者机构：

关键词： Swine acute diarrhea syndrome;coronavirus (SADS-CoV);Spike protein;Vaccine;Adenovirus vector

期刊名称： VIROLOGICA SINICA

ISSN： 1674-0769

年卷期： 2025 年 40 卷 6 期

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging bat-origin Alphacoronavirus with demonstrated zoonotic potential, poses a significant threat to swine health and has considerable economic implications. Currently, no licensed vaccines are available. We constructed a replication-deficient human adenovirus type 5 (Ad5) vectored vaccine candidate, rAd5-SADS-S, which expresses the SADS-CoV spike (S) glycoprotein. The rAd5-SADS-S vaccine elicited robust SADS-CoVspecific humoral immunity and potent cellular responses in both mice and pigs. Notably, rAd5-SADS-S conferred passive protection to neonatal mice against lethal SADS-CoV challenge. These findings establish a preclinical foundation for the development of SADS-CoV vaccines.

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