数字农科院2.0

Effects of maternal Echinococcus multilocularis infection on colitis susceptibility and gut microbiota of offspring

文献类型： 外文期刊

作者： Yihui Liu;Yang Xu;Yang Zou;Yingying Ding;Jiayun Zhang;Ying Zhang;Quanhai Pang;Shuai Wang

作者机构：

关键词： Colitis model;Echinococcus multilocularis;Foxp3;Gut microbiota;Maternal transmission

期刊名称： Parasites and Vectors

ISSN： 1756-3305

年卷期： 2025 年 18 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Background: Maternal immune modulation and alterations in gut microbiota due to intestinal helminth infections may be passed on to offspring. However, it remains unclear whether these effects can be transferred between maternal mice and their offspring during tissue-dwelling helminth infections. Methods: In this study, we investigated the effect of maternal infection with Echinococcus multilocularis (Emu) on offspring susceptibility to colitis and gut microbiota composition using a dextran sulfate sodium (DSS)-induced colitis model. We performed 16S ribosomal RNA (rRNA) sequencing to analyze the gut microbiota composition and microbial abundance in Emu-infected and control maternal mice, as well as their offspring. Results: We found that the maternal mice infected with Emu exhibited significant resistance to colitis, characterized by increased expression of Foxp3 in colonic tissue. Conversely, this resistance phenotype was not observed in the offspring of Emu-infected maternal mice, as they showed no reduction in colitis severity and demonstrated decreased Foxp3 expression. Furthermore, the gut microbiota of Emu-infected maternal mice underwent significant changes, with an increase in genera such as Rikenella, Rikenellaceae RC9 gut group, Turicibacter, Odoribacter, and Parabacteroides, while Lactobacillus, Staphylococcus, and Bifidobacterium decreased postinfection. By contrast, their offspring exhibited a markedly distinct gut microbiota shift, characterized by significant increases in Candidatus Saccharimonas, Desulfovibrio, Helicobacter, and Odoribacter, alongside significant reductions in Muribaculum and Clostridium sensu stricto 1 when compared with the offspring of naive mice. Conclusions: These findings suggest that the effects of maternal transmission concerning immune regulation and microbiota alterations in response to helminth infections may depend on species-specific factors.

分类号：

  • 相关文献

[1]Strong within-host selection in a maternally inherited obligate symbiont: Buchnera and aphids. Julie Perreau,Bo Zhang,Gerald P. Maeda,Mark Kirkpatrick,Nancy A. Moran. 2021

[2]Strong within-host selection in a maternally inherited Buchnera and. Perreau, Julie,Zhang, Bo,Maeda, Gerald P.,Kirkpatrick, Mark,Moran, Nancy A.. 2021

[3]Molecular cloning and characterization of a T24-like protein in Echinococcus multilocularis. Dang, Zhisheng,Kajino, Kiichi,Sugimoto, Chihiro,Dang, Zhisheng,Watanabe, Junichi,Oku, Yuzaburo,Matsumoto, Jun,Yagi, Kinpei,Kouguchi, Hirokazu. 2009

[4]Genome-wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome. Wang, Shuai,Wei, Wei,Cai, Xuepeng. 2015

[5]Mirna Profiling In The Mice I.n Response To Echinococcus M ultilocularis Infection. Jin, XL,Guo, XL,Zhu, DQ,Ayaz, M,Zheng, YD. 2017

[6]Regulatory Effects Of Echinococcus Multilocularis E.xtracellular Vesicles On Raw264.7 M acrophages. Zheng, YD,Guo, XL,Su, M,Guo, AJ,Ding, JT,Yang, J,Xiang, HT,Cao, XA,Zhang, SH,Ayaz, M,Luo, XN. 2017

[7]Suppression Of Mouse Mirna-222-3P In R.esponse To Echinococcus Multilocularis I nfection. Zheng, YD. 2018

[8]Identification Of Emu-Tegp11, An Ef-Hand D.omain-Containing Tegumental Protein Of E chinococcus Multilocularis. Zheng, YD,Guo, XL,Su, M,Chen, XQ,Jin, XL,Ding, JT,Wang, ZR,Bo, XW,Ayaz, M,Kutyrev, I,Jia, WZ,Zhang, XC,Zhang, J. 2018

[9]Expression Profiling Of Circulating Mirnas I.n Mouse Serum In R esponse To Echinococcus Multilocularis Infection. Guo, XL,Zheng, YD. 2017

[10]Suppression Of Nemo-Like Kinase By M.ir-71 In Echinococcus Multilocularis. Guo, XL,Zhang, XY,Yang, J,Jin, XL,Ding, JT,Xiang, HT,Ayaz, M,Luo, XN,Zheng, YD. 2017

[11]Mirna-Seq Of Echinococcus Multilocularis Extracellular Vesicles And Immunomodulatory Effects Of Mir-4989. Ding, JT, He, GT, Wu, JE, Yang, J, Guo, XL, Yang, X, Wang, Y, Kandil, OM, Kutyrev, I, Ayaz, M, Zheng, YD. 2019

[12]Molecular cloning and functional characterization of a thioredoxin peroxidase gene in Echinococcus multilocularis. Xiaola Guo,Junmei Zhang,Rui Li,Hong Li,Xuedong He,Shuai Wang,Zhengrong Wang,Majid Fasihi Harandi,Junjie Hu,Yadong Zheng. 2021

[13]Integrative Analysis of RNA Expression and Regulatory Networks in Mice Liver Infected by Echinococcus multilocularis. Liu, Tingli,Li, Hong,Li, Yanping,Wang, Liqun,Chen, Guoliang,Pu, Guiting,Guo, Xiaola,Cho, William C.,Fasihi Harandi, Majid,Zheng, Yadong,Luo, Xuenong. 2022

[14]Profiling Of Mirnas In Mouse Peritoneal Macrophages Responding To Echinococcus Multilocularis Infection. Guo, XL, Zheng, YD. 2020

[15]Characterization of fructose-1,6-bisphosphate aldolase 1 of echinococcus multilocularis. Xuedong He,Jing Zhang,Yue Sun,Tianyan Lan,Xiaola Guo,Xiaoqiang Wang,Omnia M. Kandil,Mazhar Ayaz,Xuenong Luo,Houhui Song,Yadong Zheng. 2022

[16]circRNA Expression Pattern and circRNA–miRNA–mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection. Tingli Liu,Liqun Wang,Hong Li,Yanping Li,Guoliang Chen,Guiting Pu,Xiaola Guo,Yadong Zheng,Xue Bai,Xuenong Luo. 2022

[17]Efficient delivery of Echinococcus multilocularis miRNAs using chitosan nanoparticles. Yue Sun,Yongjie Kou,Xuedong He,Yuting Yan,Xiaola Guo,Xing Yang,Naipu He,William C. Cho,Ivan Kutyrev,Majid Fasihi Harandi,Omnia M. Kandil,Xiaoqiang Wang,Houhui Song,Yadong Zheng. 2022

[18]Echinococcosis Is Associated with the Increased Prevalence of Intestinal Blastocystis Infection in Tibetans and Host Susceptibility to the Blastocystis in Mice. Zou, Yang,Wang, Yu-Gui,Liu, Zhong-Li,Guo, Ai-Jiang,Li, Xiao-Lu,Shi, Zhi-Qi,Zhu, Xing-Quan,Han, Xiu-Min,Wang, Shuai. 2022

[19]Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989. Cai, Mengting,Ding, Juntao,Li, Yating,He, Guitian,Yang, Jing,Liu, Tingli,Guo, Xiaola,Yang, Xing,Wang, Xiaoqiang,Cho, William C.,Harandi, Majid Fasihi,Zheng, Yadong. 2021

[20]Infection of sheep by Echinococcus multilocularis in Gansu, China: evidence from mitochondrial and nuclear DNA analysis. Nigus Abebe Shumuye,Li Li,Wen Hui Li,Nian Zhang Zhang,Yan Tao Wu,Yao Dong Wu,Wen Jun Tian,Lin Sheng Zhang,Xiao Feng Nian,Guo Dong Dai,Wei Gang Chen,Sheng Zhi Gao,Xue Qi Tian,Jun Shi Liu,Bin Li,Nigatu Kebede,Bao Quan Fu,Hong Bin Yan,Wan Zhong Jia. 2023

作者其他论文 更多>>