数字农科院2.0

Epitranscriptomic regulation of insecticide resistance

文献类型： 外文期刊

作者： Yang Xin;Wei Xuegao;Yang Jing;Du Tianhua;Yin Cheng;Fu Buli;Huang Mingjiao;Liang Jinjin;Gong Peipan;Liu Shaonan;Xie Wen;Guo Zhaojiang;Wang Shaoli;Wu Qingjun;Nauen Ralf;Zhou Xuguo;Bass Chris;Zhang Youjun

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期刊名称： Science Advances

ISSN： 2375-2548

年卷期： 2021 年 7 卷 19 期

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收录情况： JCR（2021版） ; EI（2021版）

摘要： N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in eukaryotes and an important posttranscriptional regulator of gene expression. However, the biological roles of m6A in most insects remain largely unknown. Here, we show that m6A regulates a cytochrome P450 gene (CYP4C64) in the global whitefly pest, Bemisia tabaci, leading to insecticide resistance. Investigation of the regulation of CYP4C64, which confers resistance to the insecticide thiamethoxam, revealed a mutation in the 5′ untranslated region of this gene in resistant B. tabaci strains that introduces a predicted m6A site. We provide several lines of evidence that mRNA methylation of the adenine at this position, in combination with modified expression of m6A writers, acts to increase expression of CYP4C64 and resistance. Collectively, these results provide an example of the epitranscriptomic regulation of the xenobiotic response in insects and implicate the m6A regulatory axis in the development of insecticide resistance. Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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