数字农科院2.0

Mining for the association of bovine mastitis linked genes to pathological signatures and Pathways

文献类型： 外文期刊

作者： Khan, Muhammad Zahoor;Belhan, Saadet;Cetin, Nebi;Ayan, Adnan;Khan, Adnan;Ahmad, Irshad;Ma, Yulin;Xiao, Jianxin;Khan, Jamal Muhammad;Shah, Muhammad Kamal;Ullah, Shakeeb;Cao, Zhijun

作者机构：

关键词： bovine mastitis; bioinformatics tools; biological signalling; genetic markers

期刊名称： ANNALS OF ANIMAL SCIENCE

ISSN： 2300-8733

年卷期： 2021 年

页码：

收录情况： JCR（2021版）

摘要： Background: Bovine mastitis is a common infectious disease with a serious threat to the dairy industry and public health. Mastitis is a polygenetic trait under the control of many genes. In the current study, our research attempted to address the role of mastitis-associated genes in various signalings including parasitic, viral, cancer and fungal diseases by using online bioinformatics software. Methods: We selected mastitis-associated genes from already published data and using online bioinformatics tools including DAVID and String classify the pathological role of relevant genes. A Venn diagram was used to show the status of overlapping genes among different biological function processes. Result: This study revealed that the genes gathered in published resources of mastitis were significantly correlated with Influenza A, Chagas disease, Leishmaniasis, Toxoplasmosis, Tuberculosis, Cancer signaling, Hepatitis B, Type I &II diabetes mellitus and Prion diseases biological pathways. Based on our findings, we concluded that mastitis-linked genes could be used as markers for many other diseases. Moreover, the Bioinformatics tools applied in the current study might be helpful in screening the genes involved in one disease and their association with other diseases as well.

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