数字农科院2.0

Ferroptosis and Its Role in Chronic Diseases

文献类型： 外文期刊

作者： Wenli Hu;Kehong Liang;Hong Zhu;Chong Zhao;Hongbo Hu;Shutao Yin

作者机构：

关键词： basic characteristics of ferroptosis;chronic diseases;ferroptosis;foodborne active ingredients;regulation of ferroptosis

期刊名称： Cells

ISSN： 2073-4409

年卷期： 2022 年 11.0 卷 13 期

页码：

摘要： Ferroptosis, which has been widely associated with many diseases, is an iron‐dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death. The course of ferroptosis can be accurately regulated by the metabolism of iron, lipids, amino acids, and various signal pathways. In this review, we summarize the basic characteristics of ferroptosis, its regulation, as well as the relationship between ferroptosis and chronic diseases such as cancer, nervous system diseases, metabolic diseases, and inflammatory bowel diseases. Finally, we describe the regulatory effects of food‐borne active ingredients on ferroptosis.

分类号：

  • 相关文献

[1]Editorial: Food-derived polyphenols: functional regulation in chronic diseases. Zhe Xu,Zhijian Tan,Jianbo Xiao,Shuzhen Cheng,Hui Chen. 2024

[2]The effect of Internet use on nutritional intake and health outcomes: new evidence from rural China. Deng, Zhilong,Liu, Jian,Hong, Yu,Liu, Weigang. 2024

[3]How does migration affect the food security and health of children and adults ?. Yuhan Zhao,Fang Xia,Xiande Li,Chen Qian,Shenggen Fan. 2025

[4]The Application and Mechanism Analysis of Enteral Nutrition in Clinical Management of Chronic Diseases. Qingye Li,Jing Wang. 2025

[5]Combined ecotoxicological effects of different-sized polyethylene microplastics and imidacloprid on the earthworms (Eisenia fetida). Fu H.,Zhu L.,Mao L.,Zhang L.,Zhang Y.,Chang Y.,Liu X.,Jiang H.. 2023

[6]Microcystin-LR induces ferroptosis in intestine of common carp (Cyprinus carpio). Yuanyuan Zhang,Di Wu,Ze Fan,Jinnan Li,Lei Gao,Yu'e Wang,Liansheng Wang. 2021

[7]Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis. Yajing Li,Zhendong Zhu,Haixiang Cui,Kexin Ding,Yong Zhao,Xiangping Ma,Adedeji Olufemi Adetunji,Lingjiang Min. 2022

[8]Phospholipid Phosphatase 3 (PLPP3) Induces Oxidative Stress to Accelerate Ovarian Aging in Pigs. Hongyan Quan,Yixuan Guo,Shuo Li,Yao Jiang,Qingpeng Shen,Yingting He,Xiaofeng Zhou,Xiaolong Yuan,Jiaqi Li. 2024

[9]Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected Macrophages. Hai Hu,Guangdong Zhang,Mingxing Tian,Xiang Guan,Yi Yin,Chan Ding,Shengqing Yu. 2023

[10]The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection Responses. Liu S.,Li Z.,Lan S.,Hao H.,Baz A.A.,Yan X.,Gao P.,Chen S.,Chu Y.. 2024

[11]Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice. Fan S.,Lin L.,Li P.,Tian H.,Shen J.,Zhou L.,Zhao Q.,Zhang J.,Qin Y.,Tang C.. 2024

[12]Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury. Shijie Fan,Jiaying Chen,Huihui Tian,Xinting Yang,Longzhu Zhou,Qingyu Zhao,Yuchang Qin,Junmin Zhang,Chaohua Tang. 2024

[13]Polyacrylic Acid-Coated Selenium-Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy-Associated Acute Kidney Injury. Li, Jiahuan,Fu, Chengcheng,Feng, Baoli,Liu, Qingquan,Gu, Jiangjiang,Khan, Mohammad Nauman,Sun, Lvhui,Wu, Honghong,Wu, Hao. 2024

[14]Brucella rough RB51 infection activates P53-Slc7a11-Gpx4/GSH pathway to induce ferroptosis to attenuate the intracellular survival on macrophages. Hai Hu,Guangdong Zhang,Mingxing Tian,Yi Yin,Yanqing Bao,Xiang Guan,Chan Ding,Shengqing Yu. 2024

[15]Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells. Sun, Yifan,Tang, Lanlan,Kan, Xianjin,Tan, Lei,Song, Cuiping,Qiu, Xusheng,Liao, Ying,Nair, Venugopal,Ding, Chan,Liu, Xiufan,Sun, Yingjie. 2024

[16]Lespedeza bicolor Turcz. Honey Prevents Inflammation Response and Inhibits Ferroptosis by Nrf2/HO-1 Pathway in DSS-Induced Human Caco-2 Cells. Caijun Ren,Yuying Zhu,Qiangqiang Li,Miao Wang,Suzhen Qi,Dandan Sun,Liming Wu,Liuwei Zhao. 2024

[17]Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages. Guangdong Zhang,Hai Hu,Yi Yin,Mingxing Tian,Zhigao Bu,Chan Ding,Shengqing Yu. 2024

[18]Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol. Yafei Wang,Xiaoning Li,Tengjiao Qu,Fenghong Huang,Jiqu Xu,Hui Gao,Shun Zhang. 2024

[19]Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. Yuhua Gao,Ningning Mi,Wenxiang Wu,Yuxuan Zhao,Fangzhou Fan,Wangwei Liao,Yongliang Ming,Weijun Guan,Chunyu Bai. 2024

[20]Transcriptomic analysis revealed ferroptosis in ducklings with splenic necrosis induced by NDRV infection. Wang, Hongzhi,Jiang, Chenchen,Xu, Boyi,Lei, Di,Fang, Rendong,Tang, Yi. 2025

作者其他论文 更多>>