数字农科院2.0

Preparation of cellulose-based nanoparticles via electrostatic self-assembly for the pH-responsive delivery of astaxanthin

文献类型： 外文期刊

作者： Gan, Miaoyu;Cao, Ailing;Cai, Luyun;Xiang, Xia;Li, Jian;Luan, Qian

作者机构：

关键词： Astaxanthin;Cellulose nanofibers;Nanoparticles;pH-responsive;Controlled release

期刊名称： FOOD CHEMISTRY

ISSN： 0308-8146

年卷期： 2024 年 463 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Oral administration of astaxanthin (AST), a potent antioxidant, is limited owing to its low solubility, physicochemical stability, and bioavailability. This study developed pH-responsive nanocarriers by the electrostatic selfassembly of 2,2,6,6-tetramethylpiperidine-1-oxyradical (TEMPO)-oxidized cellulose nanofibers (TCNFs) and chitosan (CS) to enhance the intestinal delivery of AST. The TCNF/CS@AST nanoparticles were optimized through single-factor experiments and Box-Behnken design, subsequently overcoming the hydrophobicity of AST and demonstrating improved stability against environmental stressors and controlled release in the intestinal environment. Transmission electron microscopy confirmed the near-spherical shape of these nanoparticles, with an average hydrodynamic diameter of 64 nm. TCNF/CS@AST enhanced the antioxidant effectiveness of AST after digestion and in lipopolysaccharide-stimulated RAW 264.7 cells while demonstrating good cellular compatibility. These nanoparticles present a promising strategy for the oral delivery of hydrophobic bioactive compounds orally, with potential applications in precision nutrition.

分类号：

  • 相关文献

[1]Controlled Nutrient Delivery through a pH-Responsive Wood Vehicle. Qian Luan,Hao Zhang,Chaoji Chen,Feng Jiang,Yonggang Yao,Qianchun Deng,Kaizhu Zeng,Hu Tang,Fenghong Huang. 2022

[2]Construction of novel amphiphilic chitosan copolymer nanoparticles for chlorpyrifos delivery. Zhang, Jiakun,Li, Min,Huang, Qiliang,Fan, Tengfei,Xu, Qing,Wu, Yan,Chen, Chunying.

[3]Electrospun membranes as a porous barrier for molecular transport: Membrane characterization and release assessment. Weiyi Liu,Greg Walker,Sally Price,Xiangdong Yang,Juan Li,Craig Bunt. 2021

[4]pH-Responsive Sodium Alginate Micro-Nano Hydrogels for Oral Insulin Delivery: Enhancing Therapeutic Efficacy and Reducing Hypoglycemic Risk. Kong, Minghui,Yang, Haixia,Fan, Daidi,Deng, Jianjun. 2025

[5]Honokiol-loaded nanoparticles for targeted bacterial eradication and treatment of MRSA infection. Shouli Yi,Hongjuan Zhang,Zhen Yang,Di Wu,Dan Shao,Jiongjie He,Yu Liu,Baocheng Hao,Shengyi Wang. 2025

[6]Facile isolation of cellulose nanofibers from soybean residue. Li Wang,Qihua Cui,Siwen Pan,Yige Li,Yajie Jin,Huijiao Yang,Tao Li,Qiang Zhang. 2021

[7]Exploring the potential of potato products: Puree and cellulose nanofibers, to improve the nutritional value of mayonnaise. Liu, Xiaowen,Sun, Hongnan,Mu, Taihua,Gontard, Nathalie. 2024

[8]Preparation of cellulose nanofibers from potato residues by ultrasonication combined with high-pressure homogenization. Xiaowen Liu,Hongnan Sun,Taihua Mu,Marie Laure Fauconnier,Mei Li. 2023

[9]Cellulose Nanofibers: Current Status and Emerging Development of Sources, Pretreatment, Production, and Applications. Fang, Qi,Sun, Hong-Nan,Zhang, Miao,Mu, Tai-Hua,Garcia-Vaquero, Marco. 2024

[10]Sustainable production and characterization of cellulose nanofibers from sweet potato residues via sodium percarbonate pre-treatment. Qi Fang,Hong Nan Sun,Miao Zhang,Tai Hua Mu,Marco Garcia-Vaquero. 2025

[11]Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery. Shuhan Feng,Patrick Laurén,Jacopo Zini,Zahra Gounani,Jinfeng Bi,Jianyong Yi,Timo Laaksonen. 2025

[12]A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Gao, Hui,Yang, Wei,Zhang, Li,Chen, Chang,Chen, Chang. 2014

[13]Determination of astaxanthin in feeds using high performance liquid chromatography and an efficient extraction method. Du, Pengfei,Jin, Maojun,Yang, Lihua,Chen, Ge,Zhang, Chan,Jin, Fen,Shao, Hua,Yang, Mao,She, Yongxin,Wang, Shanshan,Zheng, Lufei,Wang, Jing,Yang, Xin.

[14]Astaxanthin improved the storage stability of docosahexaenoic acid-enriched eggs by inhibiting oxidation of non-esterified poly-unsaturated fatty acids. Hao Wang,Weizhao He,Dieudonné Mahukpégo Dansou,Huiyan Zhang,Ramdhan Dwi Nugroho,Chaohua Tang,Xiaoqing Guo,Yanan Yu,Qingyu Zhao,Yuchang Qin,Junmin Zhang. 2022

[15]Beneficial effects and health benefits of Astaxanthin molecules on animal production: A review. Sayed Haidar Abbas Raza,Syeda Rida Zahra Naqvi,Sameh A. Abdelnour,Nicola Schreurs,Zuhair M. Mohammedsaleh,Imran Khan,Abdullah F. Shater,Mohamed E. Abd El-Hack,Asmaa F. Khafaga,Guobo Quan,Rajwali Khan,Sihu Wang,Gong Cheng,Linsen Zan. 2021

[16]De Novo Synthesis Of Astaxanthin: F.rom Organisms To Genes. Fang, N, Wang, CK, Liu, XF, Zhao, X, Liu, YH, Liu, XM, Du, YM, Zhang, ZF, Zhang, HB. 2019

[17]Reprogramming Microorganisms For The Biosynthesis Of Astaxanthin Via Metabolic Engineering. Wan, X, Zhou, XR, Moncalian, G, Su, L, Chen, WC, Zhu, HZ, Chen, D, Gong, YM, Huang, FH, Deng, QC. 2021

[18]Effects of duration and supplementation dose with astaxanthin on egg fortification. Dieudonné M. Dansou,Hao Wang,Ramdhan D. Nugroho,Weizhao He,Qingyu Zhao,Chaohua Tang,Huiyan Zhang,Junmin Zhang. 2021

[19]Improvement of morpho-physiological, ultrastructural and nutritional profiles in wheat seedlings through astaxanthin nanoparticles alleviating the cadmium toxicity. Ali Zeshan,Muhammad Abdullah,Muhammad Faheem Adil,Dongming Wei,Muhammad Noman,Temoor Ahmed,Shafaque Sehar,Younan Ouyang,Imran Haider Shamsi. 2022

[20]Comparison of different methods for extracting the astaxanthin from haematococcus pluvialis: Chemical composition and biological activity. Yicheng Tan,Zhang Ye,Mansheng Wang,Muhammad Faisal Manzoor,Rana Muhammad Aadil,Xinghe Tan,Zhiwei Liu. 2021

作者其他论文 更多>>