数字农科院2.0

Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas

文献类型： 外文期刊

作者： He, Yi-Lin;Huang, Pei-Zhi;Yang, Hong-Ying;Feng, Wei-Jiao;Li, Zhao-Cai;Gao, Kun

作者机构：

关键词： Euphorbiaceae;Jatropha curcas L;neolignan;jatrolignans;epimers;antichlamydial activity

期刊名称： MOLECULES

ISSN：

年卷期： 2022 年 27 卷 11 期

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摘要： Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 mu M.

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