数字农科院2.0

Synergistic developmental effects of zebrafish exposed to combined perfluorooctanoic acid and atrazine

文献类型： 外文期刊

作者： Xiaoyu Zhao;Beinan Wang;Xiao Song;Linjuan He;Wei Zhang;Yongzhong Qian;Xiyan Mu;Jing Qiu

作者机构：

关键词： Atrazine;Developmental effects;Joint toxicity;PFOA;Zebrafish embryos

期刊名称： Chemosphere

ISSN： 0045-6535

年卷期： 2024 年 358 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Perfluorooctanoic acid (PFOA) and atrazine are two endocrine disruptors that are widely found in waters. Negative effects of PFOA and atrazine have been studied individually, but few data have focused on their combined effects. Here, zebrafish embryos were used as model to investigate the combined toxicity of PFOA and atrazine. The acute toxicity of atrazine (11.9 mg/L) to zebrafish embryos was much higher than that of perfluorooctanoic acid (224.6 mg/L) as shown by the 120h-LC50 value. Developmental effects, including delayed yolk sac absorption, spinal curvature, and liver abnormalities, were observed in both one- and two-component exposures. Notably, the rate of embryonic malformations in the co-exposure group was more than twice as high as that of single component exposure in the concentration range of 1/8-1/2 EC50, which indicated a synergistic effect of the binary mixture. The synergistic effect of PFOA-atrazine was further validated by combinatorial index (CI) modeling. In addition, changes of amino acid metabolites, reactive oxygen species and superoxide dismutase indicated that oxidative stress might be the main pathway for enhanced toxicity under co-exposure condition. Overall, co-exposure of PFOA and atrazine resulted in stronger developmental effects and more complicated amino acid metabolic response toward zebrafish, compared with single component exposure.

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