数字农科院2.0

Research progress on dual pathways of plant extracts inhibiting advanced glycation end products and their gut microbiota-mediated mechanisms

文献类型： 外文期刊

作者： Meng Yao Jin;Huan Luo;Xiang Fei Han;Li Feng Li;Hua Lei Chen;Tian Yu Hou;Ya Na Zhao;He Li

作者机构：

关键词： Advanced glycation end products;Inhibitory mechanism;Maillard reaction;Pathogenesis;Plant extracts

期刊名称： Industrial Crops and Products

ISSN： 0926-6690

年卷期： 2025 年 237 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Advanced glycation end products (AGEs) are a series of stable compounds produced by non-enzymatic reactions between reducing sugars and macromolecules such as proteins, lipids, or nucleic acids. Studies have shown that the accumulation of AGEs in the body can lead to neurodegenerative and cardiovascular diseases, inflammatory responses, diabetes, and other diseases. This paper will provide an overview of the sources, classification, and pathogenesis of AGEs. Most importantly, the progress of research on plant extracts to inhibit the production of foodborne AGEs, and their effects on gut microbes are summarized. Several classes of natural plant extracts with inhibitory effects are presented, including polyphenols, polysaccharides, vitamins, alkaloids, saponins, and others, and their mechanisms of action can be summarized as covering protein glycation sites, chelating metal ions, scavenging free radicals, trapping reactive di-carbonyl compounds, lowering glucose-lipid levels, inhibiting aldose reductase, modulating the receptor for AGEs, improving insulin resistance, reducing AGEs cross-linking and protecting the glyoxalase detoxification system. Although these extracts have good inhibitory effects, none of them have been widely used in clinical trials so far, probably because of their specific mechanism of action in the human body, and we continue to study them in depth, aiming to provide a theoretical basis for the development of new therapeutic strategies and drugs.

分类号：

  • 相关文献

[1]Qualitative and quantitative assessment of key aroma compounds, advanced glycation end products and heterocyclic amines in different varieties of commercially roasted meat products. Shi, Haonan,Gao, Rongmei,Liu, Huan,Wang, Zhenyu,Zhang, Chunjiang,Zhang, Dequan. 2024

[2]GlobalgeneexpressionprofileofchickenspleentissueatalaterstageofIBVinfectionrevealspathogenesisandimmunemechanisms. FengCong,ZongxiHan,FengjieWang,YuhaoShao,XiangangKong,ShengwangLiu. 2014

[3]Effects of chestnut tannins on carcass characteristics, meat quality, lipid oxidation and fatty acid composition of rabbits. Gai, Francesco,Gasco, Laura,Brugiapaglia, Alberto,Lussiana, Carola,Zoccarato, Lvo,Liu, Hua Wei,Tong, Jian Ming,Guo, Kai Jun.

[4]Therapeutic Strategies of Plant-derived Compounds for Diabetes Via Regulation of Monocyte Chemoattractant Protein-1. Czemplik, Magdalena,Kulma, Anna,Szopa, Jan,Wang, Yu Fu,Szopa, Jan,Szopa, Jan.

[5]Inhibitory Effect of Cinnamaldehyde, Citral, and Eugenol on Aflatoxin Biosynthetic Gene Expression and Aflatoxin B-1 Biosynthesis in Aspergillus flavus. Liang, Dandan,Xing, Fuguo,Selvaraj, Jonathan Nimal,Liu, Xiao,Wang, Limin,Hua, Huijuan,Zhou, Lu,Zhao, Yueju,Wang, Yan,Liu, Yang.

[6]Powerful Stress Relieving Medicinal Plants for Anger, Anxiety, Depression, and Stress During Global Pandemic. Shahrajabian M.H.. 2022

[7]Effects of Chitosan/Collagen Peptides/Cinnamon Bark Essential Oil Composite Coating on the Quality of Dry-Aged Beef. Songshan Zhang,Xiaobin Sun,Yuanhua Lei,Baozhong Sun,Peng Xie,Xiaochang Liu. 2022

[8]Exploring the nematicidal activity of plant extracts for management of Meloidogyne incognita in local cultivars of eggplant (Solanum melongena L.) in Pakistan. Usman Arshad,Husnain Butt,Muhammad Amjad Ali,Muhammad Jabran,Muhammad Salman Zahid,Sohaib Sarfraz. 2021

[9]Effects Of Dietary Graded Levels O.f Cinnamon Essential Oil A nd Its Combination With Bamboo Leaf Flavonoid On Immune Function, Antioxidative Ability And Intestinal Microbiota Of Broilers. Yang, YF, Zhao, LL, Shao, YX, Liao, XD, Zhang, LY, Lu, L, Luo, XG. 2019

[10]Insights into the Role of Natural Products in the Control of the Honey Bee Gut Parasite (Nosema spp.). Hesham R. El-Seedi,Aida A.Abd El-Wahed,Yahya Al Naggar,Aamer Saeed,Jianbo Xiao,Hammad Ullah,Syed G. Musharraf,Mohammad H. Boskabady,Wei Cao,Zhiming Guo,Maria Daglia,Abeer El Wakil,Kai Wang,Shaden A.M. Khalifa. 2022

[11]Advances in the Application of Phytogenic Extracts as Antioxidants and Their Potential Mechanisms in Ruminants. Minyu Piao,Yan Tu,Naifeng Zhang,Qiyu Diao,Yanliang Bi. 2023

[12]Comparative Efficacy of Plant Extracts and Probiotics on Growth and Gut Health in Chickens with Necrotic Enteritis. Zhang, Ruiting,Yang, Jia,Wang, Qingjie,Hu, Dandan,Zhao, Qiping,Zhu, Shunhai,Qiao, Yu,Zhao, Fanghe,Wang, Zhongchuang,Wang, Jinwen,Yu, Yu,Han, Hongyu,Hao, Lili,Dong, Hui. 2024

[13]Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers. Uchechukwu Edna Obianwuna,Xinyu Chang,Vivian U. Oleforuh-Okoleh,Patience N. Onu,Haijun Zhang,Kai Qiu,Shugeng Wu. 2024

[14]Biphasic effects of Callicarpa nudiflora water extract on rumen fermentation in vitro and microbial communities in sheep. Wanqin Yang,Runhang Li,Wenxi Wang,Kunna Li,Yiying Huang,Ying Ying,Yuning Liu,Hongxin Wu. 2025

[15]Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1. Wei Chen,Qi Chen,Ashutosh Kumar,Xi Jiang,Kam Y. J. Zhang,Qing Yang. 2021

[16]Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1. Wei Chen,Qi Chen,Ashutosh Kumar,Xi Jiang,Kam Y. J. Zhang,Qing Yang. 2021

[17]High-throughput screening and investigation of the inhibitory mechanism of α-glucosidase inhibitors in teas using an affinity selection-mass spectrometry method. Jianjian Gao,Mengxue Zhou,Dan Chen,Jiye Xu,Zhe Wang,Jiakun Peng,Zhiyuan Lin,Shuai Yu,Zhi Lin,Weidong Dai. 2023

[18]The inhibition mechanism of quercetin targeting β-Lactamases OXA-98 based on molecular dynamics simulation. Yanan Yang,Jingcheng Song,Yue Gao,Dongxia Li,Xuenan Li,Yujia Liu. 2023

[19]Recent advances in glycoside hydrolase family 20 and 84 inhibitors: Structures, inhibitory mechanisms and biological activities. Jiang, Xi,Yang, Qing. 2024

[20]Methylparaben suppresses the citrus postharvest pathogen Penicillium digitatum by undermining the cell wall and membrane and inducing the antioxidant system. Fan Yang,Xiuying Zhong,Yuqing Wang,Juan Zhao,Yongqing Lu,Chao an Long. 2024

作者其他论文 更多>>