数字农科院2.0

High-phytosterol rapeseed oil prevents atherosclerosis by reducing intestinal barrier dysfunction and cholesterol uptake in ApoE−/− mice

文献类型： 外文期刊

作者： Yaxi Xu;Mengxue Fang;Ze Chen;Zhili Jin;Tong Zhang;Li Yu;Fei Ma;Zhibing Lu;Hairong Wang;Liangxiao Zhang;Peiwu Li

作者机构：

关键词： Atherosclerosis;Cholesterol uptake;High-phytosterol rapeseed oil;Intestinal barrier

期刊名称： Food Research International

ISSN： 0963-9969

年卷期： 2025 年 214 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Atherosclerosis (AS) is a chronic vascular disease characterized by the formation of an atherosclerotic plaque and high serum cholesterol. This study focused on the role of intestinal cholesterol uptake and barrier integrity of AS mice to investigate the anti-AS mechanism of high-phytosterol rapeseed oil (HPRO). The results showed that HPRO exhibited a significant anti-AS effect, which significantly reduced aortic plaque and serum cholesterol content, and increased aortic diameter. The comprehensive analysis of transcriptomic and metabolomic analysis on the intestine showed that HPRO mainly regulated primary bile acid biosynthesis and cholesterol metabolism. Interestingly, HPRO was found to reduce cholesterol absorption, transport, and micellar cholesterol content in the intestine, and the effect of HPRO was better than β-sitosterol. In addition, the expression of ZO-1 and occludin increased in both Caco-2 cells and the mice intestine, suggesting that HPRO can improve intestinal barrier function. Overall, these findings suggested that HPRO showed a significant preventative action on AS by reducing intestinal barrier and cholesterol intake dysfunction.

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