数字农科院2.0

Royal Jelly Alleviates Cognitive Deficits A.nd Beta-Amyloid Accumulation In A pp/Ps1 Mouse Model Via Activation Of The Camp/Pka/Creb/Bdnf Pathway And Inhibition Of Neuronal Apoptosis

文献类型： 外文期刊

作者： You, MM; Pan, YM; Liu, YC; Chen, YF; Wu, YQ; Si, JJ; Wang, K; Hu, FL

作者机构：

关键词： royal jelly; Alzheimer's disease; cognitive deficits; amyloid-beta; cAMP-response element binding protein; apoptosis

期刊名称： FRONTIERS IN AGING NEUROSCIENCE

ISSN： 1663-4365

年卷期： 2019 年 10 卷

页码：

收录情况： JCR（2021版）

摘要： Alzheimer's disease (AD) is characterized clinically by progressive cognitive decline and pathologically by the accumulation of amyloid-beta (A beta) in the brain. Royal jelly (RJ), a secretion of honeybee hypopharyngeal and mandibular glands, has previously been shown to have anti-aging and neuromodulatory activities. In this study, we discovered that 3 months of RJ treatment substantially ameliorated behavioral deficits of APP/PS1 mice in the Morris Water Maze (MWM) test and step-down passive avoidance test. Our data also showed that RJ significantly diminished amyloid plaque pathology in APP/PS1 mice. Furthermore, RJ alleviated c-Jun N-terminal kinase (JNK) phosphorylation-induced neuronal apoptosis by suppressing oxidative stress. Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline. Collectively, these results provide a scientific basis for using RJ as a functional food for targeting AD pathology.

分类号：

  • 相关文献

[1]Neuroprotective Effects Of 20(S)-Protopanaxatriol (Ppt) O.n Scopolamine-Induced Cognitive Deficits I n Mice. Lu, C, Lv, JW, Dong, LM, Jiang, N, Wang, Y, Wang, Q, Li, YH, Chen, SG, Fan, B, Wang, FZ, Liu, XM. 2018

[2]Polymorphisms Of Abcg2 And Its I.mpact On Clinical Relevance. Shi, Zhi,Sun, Shili,Zhang, Wenji,Zhang, Wenjuan,Zhang, Wenji. 2018

[3]Association Of Tea Consumption With R.isk Of Alzheimer'S Disease A nd Anti-Beta-Amyloid Effects Of Tea. Ye, Jian-Hui,Yang, Rui,Xiang, Li-Ping,Wang, Kai-Rong,Zheng, Xin-Qiang,Polito, Curt Anthony,Liang, Yue-Rong,Cai, Zhuo-Yu,Shi, Yun-Long,Li, Qing-Sheng,Ma, Shi-Cheng,Shi, Meng,Li, Xu-Min,Lu, Jian-Liang. 2018

[4]Comparison Of The Protective Effects Of Ginsenosides Rb1 And Rg1 On Improving Cognitive Deficits In Samp8 Mice Based On Anti-Neuroinflammation Mechanism. Yang, YJ, Li, SS, Huang, H, Lv, JW, Chen, SG, Dias, ACP, Li, YJ, Liu, XM, Wang, Q. 2020

[5]Quercetin: total-scale literature landscape analysis of a valuable nutraceutical with numerous potential applications in the promotion of human and animal health - a review. Yeung, Andy Wai Kan,Choudhary, Neeraj,Tewari, Devesh,El-Demerdash, Amr,Horbanczuk, Olaf K.,Das, Niranjan,Pirgozliev, Vasil,Lucarini, Massimo,Durazzo, Alessandra,Souto, Eliana B.,Santini, Antonello,Devkota, Hari Prasad,Uddin, Md. Sahab,Echeverria, Javier,Wang, Dongdong,Gan, Ren-You,Brncic, Mladen,Kalfin, Reni E.,Tzvetkov, Nikolay T.,Jozwik, Artur,Solka, Magdalena,Strzalkowska, Nina,Horbanczuk, Jaroslaw Olav,Atanasov, Atanas G.. 2021

[6]Combined Hepatotoxicity and Toxicity Mechanism of Intermedine and Lycopsamine. Wang Z., Qiao L., Zheng Q., Han H., Li Z., Zhang X., Chen H.. 2022

[7]Ginger and 6-gingerol prevent lipopolysaccharide-induced intestinal barrier damage and liver injury in mice. Guo X.-X., Zhang Y.-D., Wang T.-C., Wang X.-L., Xu Y.-Y., Wang Y., Qiu J.. 2022

[8]Differential volatile organic compounds in royal jelly associated with different nectar plants. Zhao Ya-zhou,Tian Wen-li,Fang Xiao-ming,Peng Wen-jun,Zhao Ya-zhou,Li Zhi-guo,Su Song-kun. 2016

[9]Fast Determination of Royal Jelly Freshness by a Chromogenic Reaction. Zheng, Huo-Qing,Wei, Wen-Ting,Hu, Fu-Liang,Wu, Li-Ming,Dietemann, Vincent,Dietemann, Vincent. 2012

[10]Comparative analysis of the effects of different storage conditions on major royal jelly proteins. Li, Jian-ke,Wang, Ting,Peng, Wen-jun. 2007

[11]Identification of the distribution of adenosine phosphates, nucleosides and nucleobases in royal jelly. Wu, Liming,Chen, Lanzhen,Wei, Yue,Wang, Yong,Li, Yi,Zhao, Jing,Xue, Xiaofeng,Selvaraj, Jonathan Nimal.

[12]In-Depth N-Glycosylation Reveals Species-Specific Modifications and Functions of the Royal Jelly Protein from Western (Apis mellifera) and Eastern Honeybees (Apis cerana). Feng, Mao,Fang, Yu,Han, Bin,Xu, Xiang,Fan, Pei,Hao, Yue,Qi, Yuping,Hu, Han,Huo, Xinmei,Meng, Lifeng,Wu, Bin,Li, Jianke,Fan, Pei.

[13]Isolation and characterization of proteins and lipids from honeybee (Apis mellifera L.) queen larvae and royal jelly. Xu, Xiang,Gao, Yanxiang,Xu, Xiang.

[14]Determination of tryptophan in bee pollen and royal jelly by high-performance liquid chromatography with fluorescence detection. Zhang, Jin-zhen,Xue, Xiao-feng,Zhou, Jin-hui,Chen, Fang,Wu, Li-ming,Li, Yi,Zhao, Jing. 2009

[15]Simultaneous determination of trace migration of phthalate esters in honey and royal jelly by GC-MS. Zhou, Jinhui,Diao, Qingyun,Li, Yi,Zhou, Jinhui,Li, Yi,Zhou, Jinhui,Li, Yi,Qi, Yitao,Wu, Hongmei,Tian, Feifei.

[16]Quantitative Neuropeptidome Analysis Reveals Neuropeptides Are Correlated with Social Behavior Regulation of the Honeybee Workers. Han, Bin,Fang, Yu,Feng, Mao,Hu, Han,Qi, Yuping,Huo, Xinmei,Meng, Lifeng,Wu, Bin,Li, Jianke.

[17]Research on Overall Assessment of Royal Jelly Freshness by FTIR Spectroscopy. Zhou Qun,Sun Su qin,Wu Li-ming,Zhao Jing,Wu Li-ming,Hu Fu liang. 2009

[18]Towards posttranslational modification proteome of royal jelly. Zhang, Lan,Fang, Yu,Li, Rongli,Feng, Mao,Han, Bin,Zhou, Tiane,Li, Jianke.

[19]Royal jelly proteome comparison between A. mellifera ligustica and A. cerana cerana. Fang Yu,Feng Mao,Li Jianke.

[20]Determination of melamine in royal jelly and lyophilized powder using ultrasonically assisted extraction by ion-pair HPLC with UV detection. Zhao, Jing,Zhou, Jinhui,Zhao, Jing,Xue, Xiaofeng,Chen, Fang,Zhang, Jinzhen,Li, Yi,Wu, Liming,Chen, Lanzhen.

作者其他论文 更多>>