数字农科院2.0

Effects Of Disruption Of Five F.um Genes On Fumonisin B iosynthesis And Pathogenicity In Fusarium Proliferatum

文献类型： 外文期刊

作者： Liu, Lianmeng;Huang, Shiwen;Huang, Shiwen;Zhao, Yuan;Sun, Lei;Sun, Lei;Zhao, Yuan;Wang, Ling;Chen, Xu;Hou, Yuxuan;Gao, Jian

作者机构：

关键词： Fusarium proliferatum; FUM; fumonisin; pathogenicity

期刊名称： TOXINS

ISSN： 2072-6651

年卷期： 2019 年 11 卷 6 期

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摘要： The mycotoxin fumonisin is known to be harmful to humans and animals, and thus it is desirable to reduce fumonisin content in crop products. We explored the functions of several genes that function in fumonisin biosynthesis (FUM1, FUM6, FUM8, FUM19, and FUM21) in Fusarium proliferatum and found that deletion of FUM1, FUM6, FUM8, or FUM21 results in a severe reduction in fumonisin biosynthesis, while loss of FUM19 does not. In addition, fumonisin-deficient strains display significantly decreased pathogenicity. Co-cultivation of the Delta FUM1, Delta FUM6, Delta FUM8, and Delta FUM19 mutants restores fumonisin synthesis. However, co-cultivation was unable to restore fumonisin synthesis in the Delta FUM21 strain. The relative expression levels of three key FUM genes (FUM1, FUM6, and FUM8) differed significantly in each mutant strain; notably, the expression levels of these three genes were significantly down-regulated in the Delta FUM21 strain. Taken together, our results demonstrate that FUM1, FUM6, FUM8, and FUM21 are essential for fumonisin synthesis, and FUM19 is non-essential. Partial mutants lost the ability to synthesize fumonisin, the co-culture of the mutants was able to restore fumonisin biosynthesis. While the pathogenicity of F. proliferatum is affected by many factors, inhibition of the synthesis of the mycotoxin fumonisin will weaken the pathogenicity of rice spikelet rot disease (RSRD).

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