数字农科院2.0

Immune-Related Mirna-Mrna Regulation Network In The Livers Of Dhav-3-Infected Ducklings

文献类型： 外文期刊

作者： Wu, Fengyao;Liu, Chuanmin;Lu, Fengying;Fan, Xin;Chao, Jin;Wu, Fengyao;Fan, Xin;Lu, Fengying;Sun, Huawei;Liu, Chuanmin;Pan, Qunxing;Pan, Qunxing;Zhang, Xiaofei;Sun, Huawei;Zhang, Xiaofei;Chao, Jin

作者机构：

关键词： Duck Hepatitis A Virus Type 3; Mirna; Transcriptome; Mirna-Mrna Network; Innate Immune Response; Host-Virus Interactions

期刊名称： BMC GENOMICS

ISSN： 1471-2164

年卷期： 2020 年 21 卷 1 期

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摘要： Background Duck hepatitis A virus type 3 (DHAV-3) is one of the most harmful pathogens in the duck industry. However, the molecular mechanism underlying DHAV-3 infection in ducklings remains poorly understood. To study the genetic regulatory network for miRNA-mRNA and the signaling pathways involved in DHAV-3 infection in ducklings, we conducted global miRNA and mRNA expression profiling of duckling liver tissues infected with lethal DHAV-3 by high-throughput sequencing. Results We found 156 differentially expressed miRNAs (DEMs) and 7717 differentially expressed genes (DEGs) in livers of mock-infected and DHAV-3-infected duckling. A total of 19,606 miRNA-mRNA pairs with negatively correlated expression patterns were identified in miRNA-mRNA networks constructed on the basis of these DEMs and DEGs. Moreover, immune-related pathways, including the cytokine-cytokine receptor interaction, apoptosis, Toll-like receptor, Jak-STAT, and RIG-I-like receptor signaling pathway, were significantly enriched through analyzing functions of mRNAs in the network in response to DHAV-3 infection. Furthermore, apl-miR-32-5p, apl-miR-125-5p, apl-miR-128-3p, apl-miR-460-5p, and novel-m0012-3p were identified as potential regulators in the immune-related signaling pathways during DHAV-3 infection. And some host miRNAs were predicted to target the DHAV-3 genome. Conclusions This is the first integrated analysis of miRNA and mRNA in DHAV-3-infected ducklings. The results indicated the important roles of miRNAs in regulating immune response genes and revealed the immune related miRNA-mRNA regulation network in the DHAV-3-infected duckling liver. These findings increase our knowledge of the roles of miRNAs and their target genes in DHAV-3 replication and pathogenesis. They also aid in the understanding of host-virus interactions.

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