数字农科院2.0

Synthesis of Reversible Fluorescence Quenched Probe for Cu2+ and Imaging in PK-15 cells

文献类型: 外文期刊

作者: Zhang Yingpeng;You Caixia;Yang Yunshang;Liu Xiaoyu;Dong Yuying;Guo Huichen

作者机构:

关键词: pyrazoline;fluorescent probe;copper ions;recognition;PK-15 living cells

期刊名称: CHINESE JOURNAL OF ORGANIC CHEMISTRY

ISSN: 0253-2786

年卷期: 2016 年 36 卷 6 期

页码:

收录情况: SCI

摘要: A new pyrazoline derivatre 1-(2-hydroxyphenyl)-4-(9-anthryl)-3-benzothiazole pyrazolin (P1) was designed and synthesized. The recognition properties of the target compound P1 with metal ions had been investigated by UV absorption and fluorescence spectrophotometry. The probe exhibits several favorable features, including instantaneous, reversible recognition, high sensitivity and selectivity to copper ions. Cytotoxicity test and fluorescent immunoassay results show that compound P1 has good biocompatibility and low toxicity with its IC50 value of 376.558 mu mol/L.

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