数字农科院2.0

Syntheses and in vitro Antitumor Activities of N-Acetyl Pyrazolines and Diphenyl Etheryl N-Acetyl Bis-pyrazolines

文献类型： 外文期刊

作者： Zhang Yingpeng;Tan Wei;Yang Yunshang;Sun Shiqi;Guo Huichen

作者机构：

关键词： N-acetyl pyrazoline;N-acetyl bis-pyrazoline;diphenyl ether;antitumor

期刊名称： CHINESE JOURNAL OF ORGANIC CHEMISTRY

ISSN： 0253-2786

年卷期： 2015 年 35 卷 9 期

页码：

收录情况： SCI

摘要： Seven N-acetyl pyrazolines 2a similar to 2g and seven N-acetyl bis-pyrazolines 4a similar to 4g with diphenyl etheryl moiety were synthesized and characterized by H-1 NMR,C-13 NMR, elemental analysis and ESI-MS, and their in vitro antitumor activities on A549, H1299 and MCF-7 were evaluated by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxypheny1)-2-(4-sulfophenyl-2H-tetraiolium) (MTS) assay. The results showed those compounds exhibited potent antiproliferative effects on cancer cells, among them compound 3,3'-(4,4'-diphenyl ether)-5,5'-bi[1-acetyl-5-(benzo[d][1,3]dioxo-5-yl)-2-pyrazoline] (4e) showed significantly inhibited the growth of all three kinds of cancer cells, the IC50 values of A549, H1299 and MCF-7 were 16.91, 10.09, 10.97 mu mol/L, respectively.

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