数字农科院2.0

Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3 ' untranslated region

文献类型： 外文期刊

作者： Liu, Xiaoli;Ma, Huijie;Xu, Qianqian;Sun, Nana;Han, Zongxi;Sun, Chuyang;Guo, Hongbo;Shao, Yuhao;Kong, Xiangang;Liu, Shengwang

作者机构：

关键词： Infectious bronchitis coronavirus;Recombination event;Spike glycoprotein;Nucleocapsid tissue tropism;Replication efficiency

期刊名称： VETERINARY MICROBIOLOGY

ISSN： 0378-1135

年卷期： 2013 年 162 卷 2-4 期

页码：

收录情况： SCI

摘要： An infectious bronchitis virus (IBV), ck/CH/LZJ/111113, was isolated from a H120-vaccinated chicken which showed disease suspected of IBV infection. Neutralization testing showed that ck/CH/LZJ/111113 was distinct from either the Chinese predominant IBV LX4-type or Mass-type vaccine strains. Phylogenetic analysis confirmed that ck/CH/LZJ/111113 is of the 4/91 type; however, further extensive analyses of full-length genomes identified occurrence of recombination events. Therefore, ck/CH/LZJ/111113 originated from the recombination events between ck/CH/LDL/091022- and 4/91-like strains at three switch sites located upstream of the spike (S) glycoprotein gene, and the 3' ends of S1 and nuceocapsid (N) genes, respectively. The difference of serotypes and tissue tropisms in kidneys between ck/CH/LZJ/111113 and ck/CH/LDL/091022 may have been contributed by the uptake of the S1 gene by a ck/CH/LDL/091022-like virus from a 4/91-like strain. This recombination event took place at the 3' end of the N gene and the 3' untranslated region may account for differences in replication efficiency in tissues of chickens inoculated by the two viruses. (C) 2012 Elsevier B.V. All rights reserved.

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