数字农科院2.0

Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries)

文献类型： 外文期刊

作者： Chu, M. X.;Liu, Z. H.;Jiao, C. L.;He, Y. Q.;Fang, L.;Ye, S. C.;Chen, G. H.;Wang, J. Y.

作者机构：

关键词： bone morphogenetic protein 15 gene;bone morphogenetic protein receptor IB gene;prolificacy;sheep

期刊名称： JOURNAL OF ANIMAL SCIENCE

ISSN： 0021-8812

年卷期： 2007 年 85 卷 3 期

页码：

收录情况： SCI

摘要： The Small Tailed Han is a prolific local sheep breed in China. The bone morphogenetic protein receptor 113 (BMPR-IB) gene, which affects the fecundity of Booroola Merino sheep, and the bone morphogenetic protein 15 (BMP-15) gene, which affects the fecundity of Inverdale, Hanna, Belclare, Cambridge, and Lacaune sheep, were studied as candidate genes associated with the prolificacy of Small Tailed Han sheep. Single nucleotide polymorphisms of BMPR-IB and BMP-15 genes were detected in Small Tailed Han ewes (n = 188) by PCR-RFLP. The combined effect of the 2 genes on the prolificacy of Small Tailed Han sheep was studied. The results indicated that the same FecB mutation (Q249R) occurred in the BMPR-IB gene in Small Tailed Han ewes as found in Booroola Merino ewes. The Small Tailed Han ewes with genotypes FecB(B)/FecB(B) and FecB(B)/FecB(+) had 1.40 (P < 0.01) and 1.11 (P < 0.01) more lambs, respectively, than those with genotype FecB(+)/FecB(+). The same FecX(G) mutation (Q239Ter) of the BMP-15 gene was found in Small Tailed Han ewes as in Belclare and Cambridge ewes. The Small Tailed Han ewes with the heterozygous mutant FecX(G)/FecX(+) had 0.55 (P < 0.01) more lambs than those with the wild-type FecX(+)/FecX(+). The Small Tailed Han ewes carrying mutations in both BMPR-IB and BMP-15 genes had greater litter size than those with either mutation alone. In view of our results, marker-assisted selection using both BMPR-IB and BMP-15 genes is warranted to increase litter size in sheep and will be of considerable economic value to sheep producers.

分类号：

  • 相关文献

[1]Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep. Chu, Mingxing,Fang, Li,Di, Ran,Cao, Guiling,Feng, Tao,Tang, Qianqian,Ma, Yuehui,Li, Kui,Jia, Lihua,Chen, Hongquan,Zhang, Yingjie,Jin, Mei. 2011

[2]Screening for S32G mutation of BMP15 gene in 18 goat breeds. Feng, Tao,Feng, Tao,Chu, Ming-Xing,Cao, Gui-Lin,Huang, Dong-Wei,Di, Ran,Liu, Qiu-Yue,Pan, Zhang-Yuan,Jin, Mei,Zhang, Ying-Jie. 2014

[3]Polymorphisms of BMPR-IB gene and their relationship with litter size in goats. Chu, M. X.,Di, R.,Cao, G. L.,Feng, T.,Fang, L.,Ma, Y. H.,Li, K.,Zhao, X. H.,Wang, J. Y.,Zhang, Y. J.,Jin, M..

[4]Polymorphic Study of FecX(G), FecG(H) and Fec(B) Mutations in Four Domestic Sheep Breeds in the Lower Yellow River Valley of China. Zhang, Chuan-Sheng,Geng, Li-Ying,Du, Li-Xin. 2011

[5]The genetic diversity of both FecB gene and microsatellite GC101 is associated with reproduction selection in sheep. Pan, Zhangyuan,Hu, Wenping,Di, Ran,Lin, Qinyue,Wang, Xiangyu,Yin, Dehua,Chu, Mingxing,Zhang, Baoyun,Wang, Pingqing.

[6]Polymorphisms of KiSS-1 and GPR54 genes and their relationships with litter size in sheep. Chu, Mingxing,Feng, Tao,Cao, Guiling,Fang, Li,Di, Ran,Tang, Qianqian,Huang, Dongwei,Ma, Yuehui,Li, Kui,Xiao, Chaoting,Fu, Yan,Li, Ning.

[7]Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep. He, J. N.,Chu, M. X.,Feng, T.,Di, R.,Fang, L.,Huang, D. W.,Tang, Q. Q.,Zhang, B. Y.,Wang, P. Q.,Cao, G. L.,Li, N..

[8]Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep. Liu, Qiuyue,Chu, Mingxing,Di, Ran,Feng, Tao,Geng, Caixia,Chen, Hongquan,Jin, Mei,Zhang, Yingjie,Li, Ning. 2015

[9]Association between PCR-RFLP of melatonin receptor 1a gene and high prolificacy in Small Tail Han sheep. Chu, MX,Ji, CL,Chen, GH. 2003

[10]Comparative proteomics of ovaries elucidated the potential targets related to ovine prolificacy. Chunyan Li,Mei Zhou,Xiaoyun He,Ran Di,Zijun Zhang,Chunhuan Ren,Qiuyue Liu,Mingxing Chu. 2023

[11]Thyroid Transcriptomic Profiling Reveals the Follicular Phase Differential Regulation of lncRNA and mRNA Related to Prolificacy in Small Tail Han Sheep with Two FecB Genotypes. Cheng Chang,Xiaoyun He,Ran Di,Xiangyu Wang,Miaoceng Han,Chen Liang,Mingxing Chu. 2022

[12]Association of VEGF and IGF2 Polymorphisms with Lambing Number of Small Tail Han Sheep. Peng Wang,Cai Xia Geng,Bao Yun Zhang,Hong Quan Chen,Ping Qing Wang,Yu Fang Liu,Ming Xing Chu. 2025

[13]赖氨酸对绵羊GHR基因表达的影响(英文). 李建升,程胜利,韩向敏,冯瑞林,岳耀敬,杨博辉,刘建斌. 2009

[14]基于ssRNA-seq研究差异基因、NATs对藏羊高原低氧适应的调控. 岳耀敬,冯瑞林,王天翔,郭婷婷,李桂英,孙晓萍,刘建斌,李文辉,牛春娥,郭健,李范文,杨博辉. 2015

[15]Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15). Xu, S-Z.,Gan, Q-F.,Zhang, X-H.. 2009

[16]Polymorphism in exon 2 of INHBB gene and its relationship with litter size in Jining Grey goats. Chu, M. X.,Fang, L.,Di, R.,Cao, G. L.,Feng, T.,Peng, Z. L.,Chen, H. Q.,Zhang, Y. J.,Li, N.. 2012

[17]Polymorphisms of caprine POU1F1 gene and their association with litter size in Jining Grey goats. Feng, T.,Chu, M. X.,Cao, G. L.,Tang, Q. Q.,Di, R.,Fang, L.,Li, N..

[18]Tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds. Pan, Z. Y.,Di, R.,Tang, Q. Q.,Jin, H. H.,Chu, M. X.,Huang, D. W.,He, J. N.,Liu, Q. Y.,Hu, W. P.,Wang, X. Y.,Yao, Y. X.,Liu, L.,Song, C. L..

[19]Expression Profile Analysis to Identify Circular RNA Expression Signatures in the Prolificacy Trait of Yunshang Black Goat Pituitary in the Estrus Cycle. Yufang Liu,Peng Wang,Zuyang Zhou,Xiaoyun He,Lin Tao,Yanting Jiang,Rong Lan,Qionghua Hong,Mingxing Chu. 2022

[20]Integrated Analysis of mRNAs and Long Non-Coding RNAs Expression of Oviduct That Provides Novel Insights into the Prolificacy Mechanism of Goat (Capra hircus). Sun, Zhipeng,Zhang, Zijun,Liu, Yufang,Ren, Chunhuan,He, Xiaoyun,Jiang, Yanting,Ouyang, Yina,Hong, Qionghua,Chu, Mingxing. 2022

作者其他论文 更多>>