数字农科院2.0

Humic acids alleviate dextran sulfate sodium-induced colitis by positively modulating gut microbiota

文献类型： 外文期刊

作者： Jiazhang Huang;Pengfei Xu;Mingzhi Shao;Bin Wei;Cong Zhang;Jie Zhang

作者机构：

关键词： enteritis;gut microbiota;humic substances;inflammation;traditional Chinese medicine

期刊名称： Frontiers in Microbiology

ISSN： 1664-302X

年卷期： 2023 年 14 卷

页码：

收录情况： SCIE（2023版）

摘要： Humic acids (HAs) are natural polymers with diverse functional groups that have been documented and utilized in traditional Chinese medicine. Dextran sulfate sodium (DSS)-induced colitis has been used as a model to study inflammatory bowel disease. In this research, we investigate the effect of HAs on ameliorating DSS-induced colitis in mice. Our aim here was to investigate if HAs could be a remedy against colitis and the mechanisms involved. The results show that HAs facilitated a regain of body weight and restoration of intestinal morphology after DSS-induced colitis. HAs treatment alters the community of gut microbiota with more Lactobacillus and Bifidobacterium. Changes in bacterial community result in lower amounts of lipopolysaccharides in mouse sera, as well as lower levels of inflammatory cytokines through the Toll-like receptor 4 (TLR4)-NF-κB pathway. HAs also promoted the expression of tight junction proteins, which protect the intestinal barrier from DSS damage. Cell experiments show that HAs display an inhibitory effect on DSS growth as well. These results suggest that HAs can alleviate colitis by regulating intestinal microbiota, reducing inflammation, maintaining mucosal barriers, and inhibiting pathogen growth. Thus, HAs offer great potential for the prevention and treatment of colitis.

分类号：

  • 相关文献

[1]Medicinal Herbs with Anti-Inflammatory Activities for Natural and Organic Healing. Shahrajabian, Mohamad Hesam. 2021

[2]Disordered Gut Microbiota in Colorectal Tumor-Bearing Mice Altered Serum Metabolome Related to Fufangchangtai. Cai, Mengmeng,Xiao, Ya,Lin, Zhibing,Lu, Jinmiao,Wang, Xiaoyu,Rahman, Sajid Ur,Zhu, Shilan,Chen, Xiaoyu,Gu, Jialin,Ma, Yuzhu,Chen, Zhaoguo,Huo, Jiege. 2022

[3]Oral Administration of the Antimicrobial Peptide Mastoparan X Alleviates Enterohemorrhagic Escherichia coli-Induced Intestinal Inflammation and Regulates the Gut Microbiota. Zhao, Xue Qin,Wang, Lei,Zhu, Chun Ling,Xue, Xiang Hong,Xia, Xiao Jing,Wu, Xi Long,Wu, Yun Di,Liu, Shan Qin,Zhang, Gai Ping,Bai, Yue Yu,Fotina, Hanna,Hu, Jian He. 2022

[4]Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model. Fan Wan,Mengyu Wang,Ruqing Zhong,Liang Chen,Hui Han,Lei Liu,Yong Zhao,Huiyuan Lv,Fujiang Hou,Bao Yi,Hongfu Zhang. 2022

[5]Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota. Guo, Xiaoxuan,Xu, Ye,Geng, Ruixuan,Qiu, Jing,He, Xiaoyun. 2022

[6]Cereal polyphenols inhibition mechanisms on advanced glycation end products and regulation on type 2 diabetes. Dong, Lezhen,Li, Ying,Chen, Qin,Liu, Yahui,Wu, Zufang,Pan, Daodong,Yan, Ning,Liu, Lianliang. 2023

[7]Influences of dietary Eucommia ulmoides leaf extract on the hepatic lipid metabolism, inflammation response, intestinal antioxidant capacity, intestinal microbiota, and disease resistance of the channel catfish (Ictalurus punctatus). Feng Li Zhang,Qiang Hao,Qing shuang Zhang,Hui Yuan Lv,Ya Lin Yang,Chao-Ran,Zhen Zhang,Zhi Gang Zhou. 2022

[8]Effects of tea against alcoholic fatty liver disease by modulating gut microbiota in chronic alcohol-exposed mice. Bangyan Li,Qianqian Mao,Dandan Zhou,Min Luo,Renyou Gan,Hangyu Li,Siyu Huang,Adila Saimaiti,Ao Shang,Huabin Li. 2021

[9]The role of gut microbiota in mediating increased toxicity of nano-sized polystyrene compared to micro-sized polystyrene in mice. Huai Lin,Xin Li,Huihui Gao,Wenjin Hu,Shenbo Yu,Xi Li,Liusheng Lei,Fengxia Yang. 2024

[10]Potato Resistant Starch Type 1 Promotes Obesity Linked with Modified Gut Microbiota in High-Fat Diet-Fed Mice. Zhang W.,Zhang N.,Guo X.,Fan B.,Cheng S.,Wang F.. 2024

[11]Improving fatty liver hemorrhagic syndrome in laying hens through gut microbiota and oxylipin metabolism by Bacteroides fragilis: A potential involvement of arachidonic acid. Shaobo Zhang,Manhua You,Youming Shen,Xinghua Zhao,Xin He,Juxiang Liu,Ning Ma. 2025

[12]Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis. Yanan Lv,Jing Peng,Xiaoyu Ma,Zeyi Liang,Ghasem Hosseini Salekdeh,Qunhua Ke,Wenxiang Shen,Zuoting Yan,Hongsheng Li,Shengyi Wang,Xuezhi Ding. 2024

[13]Plant-based milk alleviates antibiotics-induced intestinal barrier damage associated with modulation of gut microbiome and metabolome. Ma, Xiaoyan,Chen, Yashu,Xu, Zhenxia,Wang, Chao,Wang, Xu,Chen, Zhitao,Xu, Shufang,Yang, Chen,Deng, Qianchun. 2025

[14]Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis. Lina Huang,Zhengying Qiu,Ke Sun,Cong Yu,Qilin Huang,Chen Liu,Xiangyi Pan,Sifan Li,Shaoguang Ge,Xiongwei Shi,Fangdi Hu,Ruihua Xin. 2025

[15]Selenomethionine Regulates the Arachidonic Acid Metabolism-Ferroptosis-Inflammation Axis to Ameliorate Colitis. Tian, Huihui,Zhou, Longzhu,Feng, Xiaohui,Shen, Jialu,Du, Xiaoping,Zhao, Qingyu,Qin, Yuchang,Zhang, Junmin,Tang, Chaohua. 2026

[16]Research advances on whole grains benefit on metabolic syndrome via gut homeostasis regulation. Wang, Xinru,Liang, Hanying,Zhu, Hao,Wang, Yifang,Sun, Hongzhao,Liu, Lingyi,Xiao, Jianbo,Yan, Ning,Wang, Chuang,Liu, Lianliang. 2025

[17]Limosilactobacillus reuteri ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Challenged Mice. Xin Xu,Hongwei Zhang,Kun Meng,Hongying Cai,Weiwei Liu,Liye Song,Zihan Zhang,Qijun Zhu,Xiling Han,Yunsheng Han,Peilong Yang. 2025

[18]Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice. L. L. Fan,Q. Q. Yao,H. M. Wu,F. Wen,J. Q. Wang,H. Y. Li,N. Zheng. 2022

[19]Identification and Pathogenicity Analysis of Feline Calicivirus in Shanghai and Guangdong, China. Dan Luo,Weile Xie,Na Li,Xue Yan Peng,Kai Li,Xin Chu Zhou,Zhe Wang. 2025

[20]Cadmium and arsenic availability in soil under submerged incubation: The influence of humic substances on iron speciation. Bo Li,Qi Hong Zhu,Quan Zhang,Han Hua Zhu,Dao You Huang,Shi Ming Su,Ya Nan Wang,Xi Bai Zeng. 2021

作者其他论文 更多>>