数字农科院2.0

Largemouth bronze gudgeon (Coreius guichienoti) responds positively to liver damage induced by high feeding rates via enhancing self-repair capability

文献类型： 外文期刊

作者： Pei Chen;Xiaofang Liang;Wei Jiang;Jing Yang;Yu Zhao;Chao Lei;Huantao Qu

作者机构：

关键词： Feeding rate;Immunity;Inflammation and apoptosis;Largemouth bronze gudgeon;Lipid metabolism

期刊名称： Aquaculture

ISSN： 0044-8486

年卷期： 2025 年 597 卷

页码：

收录情况： SCIE（2025版）

摘要： Overfeeding intermittently induces metabolic liver diseases in aquaculture practice. Currently, less information regarding the impact of feeding rates on hepatic lipid metabolism was reported. Therefore, this study investigated the effects of feeding rates (2 %, 3 %, 4 %, and 5 % of body weight per day) on growth performance, hepatic lipid metabolism, immunity, inflammation, and apoptosis in juvenile largemouth bronze gudgeon (Coreius guichenoti) over 8 weeks. The results demonstrated that increasing feeding rates significantly enhanced weight gain rate and specific growth rate. Furthermore, the lipid content of the whole body increased progressively, with the highest levels observed in the 5 % group. High feeding rates also resulted in significant increases in hepatic TG, TC, and NEFA levels. This was accompanied by upregulated mRNA levels and enzyme activities of lipid synthesis-related genes (ACC1α and FASN). However, no significant differences were observed in mRNA levels and enzyme activities of lipolysis-related genes (HSL and CPT1). Histological observations identified two distinct hepatic phenotypes: no obvious abnormality liver and fatty liver. Overall, the proportion of fatty liver phenotype increased with the increasing feeding rate. Additionally, feeding rates significantly increased IgG, IgM, and lysozyme levels, and upregulated mRNA levels of inflammatory cytokines (TNFα and IL1β), apoptosis-related genes (CASP3, CASP8, and CASP9), and hepatic repair factors (YAP1, FGF10, FGF13, FGF18, FGF19, and PCNA). Nevertheless, hepatic function indices, including ALT, AST, and AKP levels, remained unchanged. In conclusion, these findings indicated that a feeding rate exceeding 3 % led to hepatic lipid metabolism disorders, characterized by the accumulation of TG and TC, thus promoting the development of fatty liver, inflammation response, and cellular apoptosis in largemouth bronze gudgeon. Moreover, the largemouth bronze gudgeon may exhibit self-repair capability to mitigate liver damage induced by lipid metabolism disorders. Consequently, we infer that largemouth bronze gudgeon possesses a robust capability for lipid accumulation and utilization.

分类号：

  • 相关文献

[1]Host adaptation plasticity in Spodoptera exigua larvae: mechanistic insights from nutritional preferences and developmental shifts in carbohydrate metabolism. Zhang, Bin,Li, Zaiyuan,Liu, Bo,Qiao, Fengjiao,Ma, Hancheng,Zheng, Guiling,Li, Jie,Yu, Qianlong,Qian, Wanqiang,Wan, Fanghao,Li, Changyou. 2025

[2]ProtectiveimmunityinducedbyaDNAvaccineexpressingeIF4AofToxoplasmagondiiagainstacutetoxoplasmosisinmice. 陈佳,SiyangHuang,ZhongyuanLi,ZiguoYuan,DonghuiZhou,EskildPetersen,NianzhangZhang,XingquanZhu. 2013

[3]表达H3N8亚型马流感病毒重组禽痘病毒载体疫苗的研究. 戚亭,郭巍,王晓钧. 2015

[4]Comparative Transcriptional Profiling of Melatonin Synthesis and Catabolic Genes Indicates the Possible Role of Melatonin in Developmental and Stress Responses in Rice. Wei, Yunxie,Zeng, Hongqiu,He, Chaozu,Shi, Haitao,Hu, Wei,Chen, Lanzhen. 2016

[5]Schistosoma japonicum: Cloning, expression and characterization of a gene encoding the alpha 5-subunit of the proteasome. Hong, Yang,Han, Hongxiao,Peng, Jinbiao,Li, Ye,Shi, Yaojun,Fu, Zhiqiang,Liu, Jinming,Lin, Jiaojiao,Hong, Yang,Han, Hongxiao,Li, Xiangrui. 2010

[6]The probiotic Bacillus licheniformis ameliorates heat stress-induced impairment of egg production, gut morphology, and intestinal mucosal immunity in laying hens. Deng, W.,Dong, X. F.,Tong, J. M.,Zhang, Q.. 2012

[7]Non-structural protein 2 of the porcine reproductive and respiratory syndrome (PRRS) virus: A crucial protein in viral pathogenesis, immunity and diagnosis. Wang, Feng-Xue,Song, Ni,Chen, Li-Zhi,Cheng, Shi-Peng,Wen, Yong-Jun,Wu, Hua. 2013

[8]Interaction of infectious bursal disease virus with the immune system of poultry. Rehman, Z. U.,Meng, C.,Ding, C.,Rehman, Z. U.,Umar, S.,Umar, S.,Munir, M..

[9]The role of porcine reproductive and respiratory syndrome virus as a risk factor in the outbreak of porcine epidemic diarrhea in immunized swine herds. Huang, Mei-Zhou,Wang, Hui,Wang, Sheng-Yi,Cui, Dong-An,Tuo, Xin,Liu, Yong-Ming. 2016

[10]Promising MS2 mediated virus-like particle vaccine against foot-and-mouth disease. Chen, Liang.

[11]Effects of lipopolysaccharide on the growth performance, nitrogen metabolism and immunity in preruminant calves. Zhang, N.,Li, H.,Jiang, C.,Tu, Y.,Diao, Q..

[12]Inhibitory effect of carboxymethylpachymaran on cyclophosphamide-induced oxidative stress in mice. Wei, Xiao-Jie,Hu, Ting-Jun,Wei, Ying-Yi,Chen, Jiong-Ran.

[13]A novel simple extracellular leucine-rich repeat (eLRR) domain protein from rice (OsLRR1) enters the endosomal pathway and interacts with the hypersensitive-induced reaction protein 1 (OsHIR1). Zhou, Liang,Cheung, Ming-Yan,Zhang, Shi-Hong,Sun, Samuel Sai-Ming,Lam, Hon-Ming,Zhou, Liang,Cheung, Ming-Yan,Zhang, Shi-Hong,Sun, Samuel Sai-Ming,Lam, Hon-Ming,Zhang, Qi,Lei, Cai-Lin,Zhang, Shi-Hong.

[14]Fusion of C3d with hemagglutinin enhances protective immunity against swine influenza virus. Li, Guo-Xin,Tian, Zhi-Jun,Yu, Hai,Jin, Yuan-Yuan,Hou, Shao-Hua,Zhou, Yan-Jun,Liu, Tian-Qiang,Hu, Shou-Ping,Tong, Guang-Zhi,Li, Guo-Xin,Tong, Guang-Zhi,Li, Guo-Xin,Yu, Hai,Zhou, Yan-Jun,Tong, Guang-Zhi.

[15]Screening of strain-specific Actinobacillus pleuropneumoniae genes using a combination method. Lei, Liancheng,Wang, Jiaqi,Lei, Liancheng,Du, Chongtiao,Yang, Peng,Xie, Fang,Ou, Pingyang,Han, Wenyu.

[16]Effects of Chinese herbal polysaccharides on the immunity and growth performance of young broilers. Chen, HL,Li, DF,Chang, BY,Gong, LM,Dai, JG,Yi, GF. 2003

[17]Effects of Long-Term Mineral Block Supplementation on Antioxidants, Immunity, and Health of Tibetan Sheep. Wang, Hui,Huang, Meizhou,Wang, Shengyi,Cui, Dongan,Dong, Shuwei,Li, Shengkun,Qi, Zhiming,Liu, Yongming,Liu, Zhiqi,Wang, Hui.

[18]Influence of Ligustrum lucidum and Schisandra chinensis fruits on antioxidative metabolism and immunological parameters of layer chicks. Ma, Deying,Liu, Yuqin,Liu, Shengwang,Li, Qundao,Shan, Anshan. 2007

[19]A de novo transcriptomic analysis to reveal functional genes in Apolygus lucorum. Liu, Yang,Wei, Jin-Jin,Li, Jian-Hong,Wang, Gui-Rong,Cao, De-Pan,Li, Jian-Hong. 2016

[20]Comparison of adhesive gut bacteria composition, immunity, and disease resistance in juvenile hybrid tilapia fed two different Lactobacillus strains. Liu, Wenshu,Gu, Zemao,Liu, Wenshu,Ren, Pengfei,He, Suxu,Xu, Li,Yang, Yaling,Zhou, Zhigang.

作者其他论文 更多>>