数字农科院2.0

Canolol and its dimer from rapeseed oil attenuate AGEs-induced endothelial cytotoxicity via modulation of MAPK/NF-κB signaling axis

文献类型： 外文期刊

作者： Huihui Liu;Chang Zheng;Nanjie Jiang;Chi Zeng;Fenghong Huang;Wenlin Li;Xia Xiang

作者机构：

关键词： AGEs;Canolol;Cytotoxicity;HUVEC cells;Signaling axis

期刊名称： Food Bioscience

ISSN： 2212-4292

年卷期： 2025 年 73 卷

页码：

收录情况： SCIE（2025版） ; ; 农林核心（2024版）

摘要： Advanced glycation end products (AGEs) are complex and heterogeneous compounds that contribute to the development of diabetes-related vascular complications. This study investigated the inhibitory effects of canolol (CAO) and its dimer, two key phenolic compounds in rapeseed oil, on AGEs-induced cytotoxicity in human umbilical vein endothelial cells (HUVECs), and elucidated their potential mechanisms of action. Both CAO and its dimer markedly alleviated AGEs-induced cytotoxicity and oxidative stress by lowering intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, while boosting glutathione (GSH) content and superoxide dismutase (SOD) activity. Moreover, they effectively suppressed AGEs-triggered apoptotic responses and preserved mitochondrial membrane potential. Additionally, CAO and its dimer inhibited AGEs-induced activation of the MAPK/NF-κB signaling axis. These findings suggested that the key phenolic compounds in rapeseed oil protect against AGEs-induced vascular endothelial injury by modulating MAPK and NF-κB pathways, offering a potential approach in for preventing and managing diabetes-related cardiovascular diseases.

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