数字农科院2.0

KLF16 inhibits PEDV replication by activating the type I IFN signaling pathway

文献类型： 外文期刊

作者： Sujie Dong;Ning Kong;Haiyan Shen;Youwen Li;Wenzhen Qin;Huanjie Zhai;Xueying Zhai;Xinyu Yang;Chenqian Ye;Manqing Ye;Changlong Liu;Lingxue Yu;Hao Zheng;Wu Tong;Hai Yu;Wen Zhang;Guangzhi Tong;Tongling Shan

作者机构：

关键词： IFN;KLF16;PEDV;Replication;TRAF6

期刊名称： Veterinary Microbiology

ISSN： 0378-1135

年卷期： 2022 年 274.0 卷

页码：

收录情况： SCIE（2022版）

摘要： KLF16, a member of KLFs (Krüppel-like factors), contributes to the progression of a variety of cancer types. There is, however, still uncertain regarding the role of KLF16 in viral replication and the signaling mechanism of type I IFN. It was discovered that KLF16 inhibited the replication of porcine epidemic diarrhea virus (PEDV) through the type I IFN signaling pathway. Besides, it can also be found that the expression of KLF16 was down-regulated after PEDV infection of LLC-PK1 cells. Furthermore, overexpression of KLF16 inhibited the replication of PEDV in Vero cells as well as LLC-PK1 cells, whereas the replication of PEDV was promoted by the knockdown of KLF16. KLF16 up-regulated the expression of interferons (IFNs) via the TRAF6-pTBK1-pIRF3 pathway with the aim of promoting the host antiviral innate immune response. In addition, the obtained findings proved that KLF16 plays a novel role in antiviral action, thereby offering novel possibilities for preventing and controlling PEDV.

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