数字农科院2.0

The ecological risk of diamide insecticide cyclaniliprole to Daphnia magna: A multi-level comprehensive analysis

文献类型： 外文期刊

作者： Yufei Zheng;Guo Tian;Jun Wang;Xiuguo Wang;Tong Liu

作者机构：

关键词： AlphaFold2;Daphnia magna;Diamide insecticide;Molecular docking;Transcriptomics

期刊名称： Environmental Pollution

ISSN： 1873-6424

年卷期： 2025 年 387 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： As a novel diamide insecticide, cyclaniliprole holds promising application prospects, making it crucial to elucidate its environmental safety. In this study, the ecological risk of cyclaniliprole to Daphnia magna (D. magna) were investigated. The findings indicated that cyclaniliprole posed a high acute toxicity risk to D. magna with LC50 value of 0.081 ± 0.004 mg/L. The reproductive capacity of the F0 generation was inhibited at 0.025 mg/L, while that of the F1 and F3 generations was not, indicating that cyclaniliprole has no obvious genotoxicity. The insecticide significantly inhibited the behavior of feeding and jumping, and induced oxidative stress and neurotoxicity in D. magna. High-throughput sequencing revealed that the number of differentially expressed genes (DEGs) increased with increasing cyclaniliprole concentrations, with significant enrichment in starch/sucrose metabolism and glutathione metabolism pathways. Further analysis revealed that cyclaniliprole disrupted calcium signaling pathways by targeting ryanodine receptors (RyR), leading to intracellular calcium imbalance, which subsequently affected motor and neurological functions. Molecular docking confirmed its strong binding affinity to RyR. This study provides crucial baseline data for environmental risk assessment of cyclaniliprole and offers methodological references for ecotoxicological research on novel insecticides.

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