数字农科院2.0

PeFtsH5 negatively regulates the biological stress response in Phalaenopsis equestris mitochondria

文献类型： 外文期刊

作者： Wu Y.;Meng Y.;Zhang L.;Yang Z.;Su M.;Jia R.;Ming F.

作者机构：

关键词： Cell apoptosis;FtsH5;Mitochondria;Phalaenopsis equestris;Virus induced gene silencing (VIGS)

期刊名称： Journal of Plant Physiology

ISSN： 0176-1617

年卷期： 2024 年 292 卷

页码：

收录情况： SCIE（2024版）

摘要： Mitochondrial homeostasis plays a crucial role in determining cell fate by direct influence on cell apoptosis and autophagy. The ATP and Zn2+-dependent protease FtsH are of paramount importance in maintaining mitochondrial homeostasis. In Phalaenopsis equestris, three mitochondrial FtsH proteases were identified, one of which was encoded by the PeFtsH5 gene. This gene encoded a distinctive mitochondrial protein featuring a unique domain within the FtsH family. Down-regulating the expression of the PeFtsH5 homolog in Nicotiana benthamiana resulted in elevated expression levels of SA synthesis-related genes, leading to enhanced disease resistance. However, this down-regulation also caused cellular damage. Similarly, in P. equestris, the down-regulation of PeFtsH5 expression promoted the expression of defense response genes, leading to accelerated apoptosis and increased ROS levels. Nonetheless, this down-regulation also positively influenced plant resistance to biotic stress. Notably, the PeFtsH5 (i-AAA) protein, as revealed by dual membrane experiments, could form homopolymers exclusively, as it did not interact with the other two mitochondrial FtsH proteases. Consequently, this mitochondrial FtsH protease functioned as a homopolymer within P. equestris cells. The findings of this study elucidated the role of PeFtsH5 in responding to biological stress and provided new insights into its potential molecular mechanism. The result presented in this study hold promise for future research endeavors examining the regulatory effects of mitochondrial proteases on mitochondrial homeostasis and the development of stress-resistant P. equestris varieties through breeding programs. © 2023 The Authors

分类号：

  • 相关文献

[1]非RIG-I依赖的鸡STING介导干扰素产生的信号通路. 程玉强,孙英杰,王恒安,严亚贤,丁铲,孙建和. 2015

[2]Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus. Wang, Gang,He, Yuli,Tu, Yabin,Liu, Yonggang,Han, Zifeng,Jiang, Chenggang,Wang, Shujie,Shi, Wenda,Cai, Xuehui,Zhou, En-Min,Han, Zifeng. 2014

[3]Combined cytotoxic effects of pesticide mixtures present in the Chinese diet on human hepatocarcinoma cell line. Ma, Mengmeng,Chen, Chen,Yang, Guiling,Li, Yun,Chen, Zhijun,Qian, Yongzhong,Yang, Guiling.

[4]Knockdown of CLAUDIN-6 Inhibited Apoptosis and Induced Proliferation of Bovine Cumulus Cells. Wang W.,Zou H.,Chen N.,Tian Y.,Hao H.,Pang Y.,Zhao X.,Zhu H.,Yu D.,Du W.. 2022

[5]Reduced mitochondrial and ascorbate-glutathione activity after artificial ageing in soybean seed. Xin, Xia,Tian, Qian,Yin, Guangkun,Chen, Xiaoling,Zhang, Jinmei,Lu, Xinxiong,Tian, Qian,Ng, Sophia,Ng, Sophia. 2014

[6]Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes. Zhao, Xue-Ming,Hao, Hai-Sheng,Du, Wei-Hua,Zhao, Shan-Jiang,Wang, Hao-Yu,Wang, Na,Wang, Dong,Liu, Yan,Qin, Tong,Zhu, Hua-Bin. 2016

[7]Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat. Xu, Feibo,Liu, Yanfen,Yu, Kaiyuan,Song, Miao,Li, Yanfei,Liu, Yanfen,Zhu, Yanzhu,Zhao, Hansong.

[8]Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers. Wang, J.,Zhang, H. J.,Samuel, K. G.,Long, C.,Wu, S. G.,Yue, H. Y.,Qi, G. H.,Sun, L. L..

[9]A phosphopantetheinyl transferase that is essential for mitochondrial fatty acid biosynthesis. Guan, Xin,Nikolau, Basil J.,Guan, Xin,Abramson, Alex,Nikolau, Basil J.,Chen, Hui,Man, Huimin,Wu, Jinxia,Yu, Oliver,Chen, Hui,Man, Huimin,Abramson, Alex,Wu, Jinxia,Yu, Oliver,Nikolau, Basil J..

[10]AlCl3 induces lymphocyte apoptosis in rats through the mitochondria-caspase dependent pathway. Li, Miao,Song, Miao,Ren, Li-Min,Xiu, Chun-Yu,Liu, Jian-Yu,Li, Yan-Fei,Liu, Jian-Yu,Zhu, Yan-zhu.

[11]Separation of motile sperm for in vitro fertilization from frozen-thawed bull semen using progesterone induction on a microchip. Li, Jingchun,Ning, Bolin,Luo, Yinghua,Guo, Li,Wei, Guosheng,Liu, Shengjun,Zhang, Ying,Zhang, Aizhong,Wu, Rui,Li, Yanbing,Cao, Xinyan.

[12]Sulfated lentinan induced mitochondrial dysfunction leads to programmed cell death of tobacco BY-2 cells. Wang, Jie,Shen, Lili,Qian, Yumei,Yang, Jinguang,Wang, Fenglong,Wang, Yaofeng.

[13]Mitochondrial proteins differential expression during honeybee (Apis mellifera L.) queen and worker larvae caste determination. Begna, Desalegn,Fang, Yu,Feng, Mao,Li, Jianke.

[14]The E-subgroup Pentatricopeptide Repeat Protein family in Arabidopsis thaliana and confirmation of the responsiveness PPR96 to abiotic stresses. 刘佳明,徐兆师. 2016

[15]African swine fever virus pe199l induces mitochondrial-dependent apoptosis. Tingting Li,Gaihong Zhao,Taoqing Zhang,Zhaoxia Zhang,Xin Chen,Jie Song,Xiao Wang,Jiangnan Li,Li Huang,Lili Wen,Changyao Li,Dongming Zhao,Xijun He,Zhigao Bu,Jun Zheng,Changjiang Weng. 2021

[16]Mitofusins: from mitochondria to fertility. Zhao, Shanjiang,Heng, Nuo,Wang, Huan,Wang, Haoyu,Zhang, Haobo,Gong, Jianfei,Hu, Zhihui,Zhu, Huabin. 2022

[17]Integrated proteomic and metabolomic analyses reveal significant changes in chloroplasts and mitochondria of pepper (Capsicum annuum L.) during Sclerotium rolfsii infection. Liao, Hongdong,Wen, Xiangyu,Deng, Xuelei,Wu, Yonghong,Xu, Jianping,Li, Xin,Zhou, Shudong,Li, Xuefeng,Zhu, Chunhui,Luo, Feng,Ma, Yanqing,Zheng, Jingyuan. 2022

[18]SYNJ2BP Improves the Production of Lentiviral Envelope Protein by Facilitating the Formation of Mitochondrion-Associated Endoplasmic Reticulum Membrane. Duan, Yingyi,Wang, Xinhui,Sun, Kehui,Lin, Yuezhi,Wang, Xuefeng,Chen, Kewei,Yang, Guangpu,Wang, Xiaojun,Du, Cheng. 2022

[19]Effects of OsAOX1a Deficiency on Mitochondrial Metabolism at Critical Node of Seed Viability in Rice. Jing Ji,Shuangshuang Lin,Xia Xin,Yang Li,Juanjuan He,Xinyue Xu,Yunxia Zhao,Gefei Su,Xinxiong Lu,Guangkun Yin. 2023

[20]Chenodeoxycholic Acid (CDCA) Promoted Intestinal Epithelial Cell Proliferation by Regulating Cell Cycle Progression and Mitochondrial Biogenesis in IPEC-J2 Cells. Xu, Lei,Li, Yanpin,Wei, Zixi,Bai, Rong,Gao, Ge,Sun, Wenjuan,Jiang, Xianren,Wang, Junjun,Li, Xilong,Pi, Yu. 2022

作者其他论文 更多>>