数字农科院2.0

Reviving hope: Phage therapy application for antimicrobial resistance in farm animal production over the past decade

文献类型： 外文期刊

作者： Mebratu Melaku;Junhong Wang;Yining Xie;Awais Ali;Bao Yi;Teng Ma;Ruqing Zhong;Liang Chen;Hongfu Zhang

作者机构：

关键词： Antimicrobial resistance (AMR);Food animal production;Phage therapy;Post-antibiotic era

期刊名称： Animal Feed Science and Technology

ISSN： 0377-8401

年卷期： 2025 年 324 卷

页码：

收录情况： SCIE（2025版）

摘要： The growing concern over antibiotic resistance on a global scale has led to a surge in phage therapy as a potential solution for difficult bacterial infections in animal production. Antibiotic resistance is a pressing public health concern affecting millions of people worldwide. Developing new antibiotics to combat this silent pandemic is complex, time-consuming process, and vulnerable to the rapid evolution of bacterial resistance. Viruses known as phages (bacteriophages) are living drugs that effectively target and destroy harmful bacteria and hold promise as valuable, green, and natural alternatives to antibiotics in food animal production. Phage therapy, which involves phages to eliminate bacterial infections, represents one of the most promising approaches to address the current threat of antibiotic resistance owing to its unique mechanisms of action. This review aims to summarize recent advances within the past years from 2014 to 2024 in the use of dietary phages as alternatives to antibiotics in food animal production. The application of phages, also known as phage therapy, occurred during the pre-antibiotic era. With antibiotics losing their effectiveness in treating zoonotic diseases and affecting the efficiency of food animal production, it is time to reconsider and renew our approach to phage therapy in the current post-antibiotic era. This review explores the development, advantages and challenges of phage therapy, its applications in food animal production and gaps for future research. It provides new insight into antibiotic resistance and the development of phage therapy cocktails that target specific antimicrobial resistance (AMR). This is important for ensuring sustainable antibiotic-free food animal production and protecting natural ecosystems.

分类号：

  • 相关文献

[1]Antibiotic resistance is the quintessential One Health issue. Robinson, T. P.,Bu, D. P.,Carrique-Mas, J.,Fevre, E. M.,Gilbert, M.,Grace, D.,Hay, S. I.,Jiwakanon, J.,Kakkar, M.,Kariuki, S.,Laxminarayan, R.,Lubroth, J.,Magnusson, U.,Ngoc, P. Thi,Van Boeckel, T. P.,Woolhouse, M. E. J.. 2016

[2]Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, including in Human and Poultry. Zhang Y.,Lin Y.,Galgano S.,Houdijk J.,Xie W.,Jin Y.,Lin J.,Song W.,Fu Y.,Li X.,Chui W.,Kan W.,Jia C.,Hu G.,Li T.. 2022

[3]The Post-Antibiotic Era: A New Dawn for Bacteriophages. Youshun Jin,Wei Li,Huaiyu Zhang,Xuli Ba,Zhaocai Li,Jizhang Zhou. 2023

[4]Improving the safety and efficacy of phage therapy from the perspective of phage-mammal interactions. Geng Zou,Lijun He,Jing Rao,Zhiyong Song,Hu Du,Runze Li,Wenjing Wang,Yang Zhou,Lu Liang,Huanchun Chen,Jinquan Li. 2023

[5]Isolation and Characterization of Three Pseudomonas aeruginosa Viruses with Therapeutic Potential. Xiao Wang,Jingjing Tang,Wen Dang,Zhen Xie,Fuhua Zhang,Xinwei Hao,Sihuai Sun,Xuan Liu,Yi Luo,Mengyuan Li,Yanchao Gu,Yao Wang,Qiwei Chen,Xihui Shen,Lei Xu. 2023

[6]Isolation and characterization of multi-drug-resistant Microbacterium esteraromaticum bacteriophage: assessment of antibacterial efficacy and genomic insights. Cheng, Shenwei,Wang, Hao,Zhang, Keqiang,Liu, Fuyuan,Gao, Xingliang,Du, Lianzhu. 2025

[7]Isolation, characterization, and application of the novel polyvalent bacteriophage vB_EcoM_XAM237 against pathogenic Escherichia coli. Chai, Jiyun,Sun, Hongfei,Schwarz, Stefan,Huang, Yuxuan,Xie, Shuangyu,Xu, Qiu,Lin, Longhua,Ma, Caiping,Hou, Jie,Zhu, Yao,Zhang, Wanjiang. 2025

[8]Effectiveness of newly isolated bacteriophages targeting multidrug-resistant Extraintestinal Pathogenic Escherichia coli strain (TZ1_3) in food preservation and mice health modulation. Youshun Jin,Wei Li,Hafiz Muhammad Hamza Rasool,Xuan Ning,Xuli Ba,Yidan Gao,Xinyu Guo,Tao Ran,Jizhang Zhou. 2025

作者其他论文 更多>>