数字农科院2.0

Antimicrobial Peptides From the Gut Microbiome of the Centenarians: Diversification of Biosynthesis and Youthful Development of Resistance Genes

文献类型： 外文期刊

作者： Chunrong Lu;Xiaojun Wang;Pengpeng Ye;Zhilong Lu;Jie Ma;Weifei Luo;Shuai Wang;Xiaochun Chen

作者机构：

关键词： Antimicrobial peptides;Gut microbes;Machine learning;Metagenome-assembled;Resistance genes

期刊名称： The journals of gerontology. Series A, Biological sciences and medical sciences

ISSN： 1758-535X

年卷期： 2024 年 79 卷 11 期

页码：

收录情况： SCIE（2024版） ; ; SSCI（2024版）

摘要： Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic crisis owing to their antimicrobial properties, and the human gut biome may be a source of these peptides. However, the potential AMPs and AMP resistance genes (AMPRGs) of gut microbes in different age groups have not been thoroughly assessed. Here, we investigated the potential development of AMPs and the distribution pattern of AMPRGs in the gut microbiome at different ages by analyzing the intestinal metagenomic data of healthy individuals at different life stages (CG: centenarians group n = 20; OAG: older adults group: n = 15; YG: young group: n = 15). Age-related increases were observed in the potential AMPs within the gut microbiome, with centenarians showing a greater diversity of these peptides. However, the gut microbiome of the CG group had a lower level of AMPRGs compared to that of the OAG group, and it was similar to the level found in the YG group. Additionally, conventional probiotic strains showed a significant positive correlation with certain potential AMPs and were associated with a lower detection of resistance genes. Furthermore, comparing potential AMPs with existing libraries revealed limited similarity, indicating that current machine learning models can identify novel peptides in the gut microbiota. These results indicate that longevity may benefit from the diversity of AMPs and lower resistance genes. Our findings help explain the age advantage of the centenarians and identify the potential for antimicrobial peptide biosynthesis in the human gut microbiome, offering insights into the development of antimicrobial peptide resistance and the screening of probiotic strains.

分类号：

  • 相关文献

[1]Expression and characterization of recombinant gallinacin-9 and gallinacin-8 in Escherichia coli. Ma, De-ying,Shan, An-shan,Liu, Sheng-wang,Han, Zong-xi,Li, Yi-jin.

[2]Effects of spinetoram and glyphosate on physiological biomarkers and gut microbes in Bombus terrestris. Qi He Tang,Wan Li Li,Jie Ping Wang,Xi Jie Li,Dan Li,Zhe Cao,Qi Huang,Jia Li Li,Jun Zhang,Zheng Wei Wang,Jun Guo,Ji Lian Li. 2023

[3]Study on the intervention mechanism of Ganoderma lucidum polysaccharides in mice with atopic dermatitis. Dexi Zhang,Yawen Wei,Xiangyang Zhu,Le Zong,Meng Cui,Dapeng Li,Chen Zhang. 2025

[4]Detached-petiole inoculation method to evaluate Phytophthora root rot resistance in soybean plants. Li, Yinping,Sun, Suli,Zhong, Chao,Zhu, Zhendong.

[5]Loci and candidate gene identification for resistance to Sclerotinia sclerotiorum in soybean (Glycine max L. Merr.) via association and linkage maps. Han, Yingpeng,Sun, Mingming,Zhao, Yue,Lv, Chunmei,Li, Dongmei,Teng, Weili,Li, Wenbin,Li, Yinghui,Qiu, Lijuan,Liu, Dongyuan,Yang, Zhijiang,Huang, Long,Zheng, Hongkun,Sun, Mingming,Lv, Chunmei.

[6]PRSRW: AN EXPERT SYSTEM FOR POSTULATING AND INFERRING RESISTANCE GENES TO WHEAT STRIPE RUST. Yang, Yu,Wang, Lianzhi,Bian, Qiang,Xu, Shichang,Wang, Fengle. 2009

[7]Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis. Huang, Xuehui,Zhao, Yan,Feng, Qi,Gong, Hao,Li, Wenjun,Zhan, Qilin,Liu, Kunyan,Zhu, Chuanrang,Huang, Tao,Zhao, Qiang,Zhang, Lei,Fan, Danlin,Zhou, Congcong,Lu, Yiqi,Weng, Qijun,Wang, Zi-Xuan,Han, Bin,Yang, Shihua,Gong, Junyi,Cheng, Benyi,Xia, Junhui,Chen, Neng,Hao, Zhongna,Li, Jiayang.

[8]Genetics and molecular mechanisms of resistance to powdery mildews in tomato (Solanum lycopersicum) and its wild relatives. Seifi, Alireza,Gao, Dongli,Zheng, Zheng,Pavan, Stefano,Faino, Luigi,Visser, Richard G. F.,Wolters, Anne-Marie A.,Bai, Yuling,Zheng, Zheng,Pavan, Stefano.

[9]Postulation of Seedlings Resistance Genes to Yellow Rust in Commercial Wheat Cultivars from Yunnan Province in China. Li Ming-ju,Feng Jing,Un Rui-ming,Chen Wan-quan,Xu Shi-chang,Li Ming-ju,Cao Shi-qin,Cheng Geng,Yu Ya-xiong. 2011

[10]Genetic Analysis of Chinese Differential Cultivar Early Premium for Yellow Rust Resistance Genes. Feng, Jing,Gan, Ai-Hua,Lin, Rui-Ming,Xu, Shichang. 2011

[11]Large-scale identification of wheat genes resistant to cereal cyst nematode Heterodera avenae using comparative transcriptomic analysis. Wu, Du-Qing,Huang, Wen-Kun,Peng, Huan,Wang, Gao-Feng,Cui, Jiang-Kuan,Liu, Shi-Ming,Peng, De-Liang,Li, Zhi-Gang,Yang, Jun,Li, Zhi-Gang,Yang, Jun. 2015

[12]Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China. Wang, Xiu-Mei,Dong, Zhimin,Zhu, Yao,Hua, Xin,Zhang, Yanhe,Liu, Siguo,Zhang, Wan-Jiang,Schwarz, Stefan.

[13]Identification of Resistant Germplasm and Detection of Genes for Resistance to Powdery Mildew and Leaf Rust from 2,978 Wheat Accessions. Yuli Jin,Fengyu Shi,Weihua Liu,Xiaoyi Fu,Tiantian Gu,Guohao Han,Zhipeng Shi,Yuan Sheng,Hongxing Xu,Lihui Li,Diaoguo An. 2021

[14]Characterization of wheat monogenic lines with known Sr genes and wheat cultivars for resistance to three new races of Puccinia graminis f. sp. tritici in China. Xian xin WU,Chao qun ZANG,Ya zhao ZHANG,Yi wei XU,Shu WANG,Tian ya LI,Li GAO. 2023

[15]Identification of Resistant Germplasm and Detection of Genes for Resistance to Powdery Mildew and Leaf Rust from 2,978 Wheat Accessions. Yuli Jin,Fengyu Shi,Weihua Liu,Xiaoyi Fu,Tiantian Gu,Guohao Han,Zhipeng Shi,Yuan Sheng,Hongxing Xu,Lihui Li,Diaoguo An. 2022

[16]Introgression of bacterial blight resistance genes in the rice cultivar ciherang: Response against xanthomonas oryzae pv. oryzae in the f6 generation. Priya Lal Biswas,Ujjal Kumar Nath,Sharmistha Ghosal,Gayatri Goswami,Md Shalim Uddin,Omar M. Ali,Arafat Abdel Hamed Abdel Latef,Alison M. Laing,Yong Ming Gao,Akbar Hossain. 2021

[17]Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis. Qiang Chen,Wensi Zhou,Yuening Cheng,Guisheng Wang,Zhihao San,Li Guo,Liming Liu,Cuiqing Zhao,Na Sun. 2024

[18]Whole-genome sequencing of multidrug-resistant Klebsiella pneumoniae with capsular serotype K2 isolates from mink in China. Na Sun,Yong Yang,Guisheng Wang,Li Guo,Liming Liu,Zhihao San,Cuiqing Zhao,Lifeng Zhao,Mingwei Tong,Yuening Cheng,Qiang Chen. 2024

[19]Stripe rust resistance in historical wheat cultivars at seedling and adult plant stages and tagging effective resistance genes using molecular markers. Majeed, Khawar,Sufyan, Muhammad,Abbasi, Kainat,Ahsan, Rafia,Bux, Hadi,Zakria, Muhammad,Fayyaz, Muhammad,Mirza, Javed Iqbal,Ali, Mohsin,Rasheed, Awais,He, Zhonghu. 2025

[20]The battle within: Discovering new insights into phytopathogen interactions and effector dynamics. Mehran Khan,Atul Kumar Srivastava,Mir Muhammad Nizamani,Muhammad Asif,Ali Kamran,Lingfeng Luo,Sanwei Yang,Songshu Chen,Zhiqiang Li,Xin Xie. 2025

作者其他论文 更多>>