数字农科院2.0

Molecular Basis for the Selectivity of the Succinate Dehydrogenase Inhibitor Cyflumetofen between Pest and Predatory Mites

文献类型： 外文期刊

作者： Li, Jinhang;Wei, Peng;Qin, Juan;Feng, Kaiyang;Shen, Guangmao;Dou, Wei;Zhang, Youjun;Cao, Peng;Yuchi, Zhiguang;Leeuwen, Thomas Van;He, Lin

作者机构：

关键词： SDHI acaricides;mites;non-target organisms;selectivity;CRISPR-Cas9;IPM

期刊名称： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN： 0021-8561

年卷期： 2023 年 71 卷 8 期

页码：

收录情况： SCIE（2023版） ; ; EI（2023版）

摘要： Acaricides that act as inhibitors of the mitochondrial succinate dehydrogenase (SDHIs) provide excellent control of phytophagous mites but display limited toxicity to predatory mites and other beneficial organisms. However, the molecular mechanism of selectivity is not fully understood. Here, we first confirm that SDHI acaricides are over 10,000-fold more toxic to spider mites than predatory mites. Next, we show that differential penetration, pro-acaricide activation, or metabolism are most likely not the main reason for this selectivity. In contrast, the inhibition of AB-1 on the SDH target is approximately 200-fold more potent in spider mites compared to predatory mites, revealing strong target-site selectivity. Strikingly, a key motif associated with differential binding was identified and validated by gene editing in Drosophila. Our findings contribute to understanding the selectivity of SDHIs, which can be used for the rational design of selective acaricides in support of an integrated pest management.

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