数字农科院2.0

岩藻多糖对大鼠氧化应激的缓解作用研究

文献类型： 中文期刊

作者： 徐元庆;张静;王哲奇;红雷

作者机构：

关键词： 岩藻多糖;氧化应激;抗氧化酶;Nrf2;大鼠

期刊名称：天然产物研究与开发

ISSN： 1001-6880

年卷期： 2023 年

页码：

收录情况： CSCD（2023-2024年度） ; ; 科技核心（2023版）

摘要： 为了探讨岩藻多糖对大鼠氧化应激的缓解作用，选择28只8周龄SD雄性大鼠，随机分为3个处理组，分别为对照组（n = 10）注射生理盐水和饲喂维持日粮；氧化应激组（n = 9）腹腔注射10 mg/kg BW的敌草快和饲喂维持日粮；氧化应激与岩藻多糖联合处理组（n = 9）注射10 mg/kg BW的敌草快（diquat）并饲喂添加250 mg/kg岩藻多糖的试验日粮。试验第12 d，氧化应激组和联合处理组大鼠腹腔注射敌草快，建立氧化应激模型。试验结束后，采集血液、肝脏和脾脏组织样品。结果显示，饲喂岩藻多糖缓解氧化应激诱导的大鼠血清中天门冬氨酸氨基转移酶（AST）活性的升高，降低肝脏中丙二醛（MDA）含量，并逆转由氧化应激诱导的肝脏组织中核转录因子E2相关因子2（Nrf2）、超氧化物歧化酶2（SOD2）和谷胱甘肽过氧化物酶（GPx）基因表达的下调，从而提高总抗氧化能力（T-AOC）和GPx活性。此外，饲喂岩藻多糖能够逆转氧化应激诱导的大鼠脾脏组织中Nrf2和GPx基因表达的下调，从而提高大鼠脾脏组织中T-AOC及SOD和GPx的活性。因此，岩藻多糖通过Nrf2途径调控大鼠肝脏和脾脏的抗氧化酶活性来缓解大鼠氧化应激。

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