数字农科院2.0

Phosphine-Catalyzed [3+2] and [2+4] Annulations of Ketenimines with Electron-Deficient Alkenes or α,β-Unsaturated Carbonyl Compounds

文献类型： 外文期刊

作者： Sun, Honghao;Ding, Siyuan;Zhang, Yingying;Zhu, Yuxin;Zhou, Leijie;Wang, Bo;Guo, Hongchao

作者机构：

期刊名称： ORGANIC LETTERS

ISSN： 1523-7060

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Phosphine-catalyzed annulation reactions of allenoates represent a powerful strategy for constructing carbo- and heterocyclic compounds. However, applications involving heteroatom surrogates of allenes remain scarce. Herein we report the first example of ketenimines serving as phosphine acceptors to enable divergent [3 + 2] and [2 + 4] annulations with thiazolone-derived alkenes, delivering fused and spirocyclic thiazole derivatives through modulation of beta '-substituents on ketenimines. This protocol achieves high yields, broad substrate scope, scalability, and applicability to further transformations. This work demonstrates the potential of ketenimines as aza surrogates of allenoates in phosphine catalysis, introducing heteroatom diversity beyond carbon/oxygen while retaining high reactivity and a broad reaction scope.

分类号：

  • 相关文献
作者其他论文 更多>>