数字农科院2.0

Metabolites Discovery from Streptomyces xanthus: Exploring the Potential of Desert Microorganisms

文献类型： 外文期刊

作者： Xinrong Luo;Zhanwen Liu;Zhanfeng Xia;Xiaoxia Luo;Juan Zhang;Ailiang Chen;Haoxin Wang;Chuanxing Wan;Lili Zhang

作者机构：

关键词： actinomycete;genomics;metabolomics;polyphasic taxonomy;Taklamakan desert;thiolutin

期刊名称： Biology

ISSN： 2079-7737

年卷期： 2025 年 14 卷 2 期

页码：

收录情况： SCIE（2025版）

摘要： The Taklamakan Desert is an extreme environment supporting a unique and diverse microbial community with significant potential for exploration. Strain TRM70308T, isolated from desert soil, shares 98.43% 16S rRNA gene sequence similarity with Streptomyces alkaliterrae OF1T. Polyphasic taxonomy confirmed TRM70308T as a novel species, named Streptomyces xanthus. Genomic analysis revealed that only one of the strain’s 25 biosynthetic gene clusters (BGCs) formed a cluster of gene families (CGFs) within the MIBiG database, emphasizing its genomics uniqueness. LC-MS/MS and Feature-Based Molecular Networking (FBMN) identified 33 metabolites across various categories, including alkaloids, saponins, benzoic acids, and benzofurans, most of which remain uncharacterized. Further chemical investigation led to the isolation of one novel compound, aconicarpyrazine C, and four known compounds: thiolutin, dibutyl phthalate, bis(2-ethylhexyl) phthalate, and N-acetyltryptamine. Thiolutin exhibited strong activity against five local fungal pathogens that cause plant diseases, with a production yield of 270 mg/L. These results establish a foundation for pilot-scale thiolutin production and its potential development as an antifungal agent for agricultural applications. Our findings highlight deserts as a valuable source of novel actinomycetes and bioactive natural products with immense potential for future research and development.

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